Neuroscientists are talking about newly discovered links between the
blood and brain at the molecular level.



Although nerve fibers and blood vessels are closely associated
throughout human body, how this shadowlike pairing becomes established
has not been clear. But a report from the recent Society for
Neuroscience Meeting in Atlanta announced that a protein familiar to
scientists as a powerful stimulant for sprouting blood vessel
growth-VEGF (Vascular Endothelial Growth Factor)-has the same potent
effect on nerves.



Peter Carmeliet <http://www.kuleuven.be/cv/u0021003e.htm>   of the
Flanders Interuniversity Institute for Biotechnology <http://www.vib.be>
in Belgium reported that VEGF released by nerve cells and glia provides
a navigation signal guiding the direction of growing nerve fibers, much
the same way blood vessels are stimulated to grow toward the same
protein. In addiction to engendering new neurons, VEGF protects neurons
from lack of oxygen after a stroke.



This factor can also guard mice against a form of Amyotrophic Lateral
Sclerosis (ALS), a degenerative neuron disease famous for killing
legendary baseball player Lou Gehrig and crippling renowned physicist
Stephen Hawking Restoring normal levels of VEGF in these animals rescues
them from death and stimulates new nerve sprouts to form synapses on
muscle fibers. The finding could lead to new treatments for many
neurodegenerative diseases, including Parkinson�s disease,
Alzheimer�s disease, multiple sclerosis and epilepsy.



Perhaps it should not come as a surprise to find the same growth-
promoting protein in bloods vessels at work in the nerves. Simple
animals, such as microscopic nematode worms, such as microscopic
nematode worms, needs a nervous system to sense food and pursue it, but
because they are so small they get all the oxygen they need without a
circulatory system. Scientists may have discovered VEGF�s
circulatory role first, but Carmeliet concludes that VEGF must have
originated in nerves and only later in evolution was it adapted to
control the growth of  blood vessels.




Happy Learning,

Yovan P. Putra

www.primastudy.com <http://www.primastudy.com/>

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