[ccp4bb] Crystallization Scientist position at Syngenta
*Senior Crystallization Scientist* Jealott's Hill, Bracknell, Berkshire, UK We are seeking a highly talented and motivated crystallization scientist who is enthusiastic about working on a wide variety of biological systems. The successful candidate will have a strong background in structural biology and will be skilled at protein crystallization, crystal optimization and protein engineering for crystallography. Experience in X-ray data collection and knowledge of x-ray structure analysis is a plus. The successful candidate will work as part of a team providing x-ray crystallography outputs to support chemistry design throughout RD. Excellent oral and written communication skills and the ability to work in multidisciplinary project teams are highly desirable qualities for this position. *Responsibilities* • Carry out crystallization trials, crystal optimization and initial characterization by x-ray diffraction for proteins and protein-ligand complexes • Perform biophysical characterization of proteins intended for crystallization • Provide guidance for the design of optimal constructs for protein crystallography • Effectively communicate results through presentations, e-mails and reports. • Develop and further own skills in theoretical and practical crystallography and structural biology through appropriate reading and attendance at courses and external meetings. Actively seek to broaden understanding of other disciplines. *Experience required* • PhD or MSc degree in structural biology or a related field • 3-5 years experience in practical macromolecular crystallography, ideally across a wide range of protein families • Working experience in design, production and purification of proteins and protein-ligand complexes specifically for protein crystallography • Knowledge of protein crystallization and optimization techniques • Knowledge of x-ray diffraction and basic data collection strategies • Knowledge of software for molecular biology and protein structure analysis *About Syngenta* Syngenta is one of the world’s leading companies with more than 27.000 employees in over 90 countries dedicated to our purpose: Bringing plant potential to life. Through world-class science, global reach and commitment to our customers we help to increase crop productivity, protect the environment and improve health and quality of life. For more information about us please go to http://www.syngenta.com/. For a full job profile and to apply to this position, please visit http://www.syngentajobs.com/Taleo_apply.html?CountryCode=2gblang=enlocation=23236270036668portal=101430233 - job number 14038910 I am happy to answer informal questions about the position, but if you wish to apply please do so via the Syngenta Careers website linked above. The position will be open until August 4. Thanks, Daniel Kloer Head of Protein Analysis and Computational Chemistry Syngenta
[ccp4bb] Position available at Syngenta - Team Leader Protein Crystallography
*Team Leader Protein Crystallography* Jealott's Hill, Bracknell, Berkshire, UK We are seeking a highly talented and motivated crystallographer who is enthusiastic about working across the range of protein crystallography activities covering a wide variety of biological systems. The successful candidate will have a strong background in protein production and crystallization as well as x-ray data collection, structure refinement and validation. Computational and molecular modelling skills are a plus. The successful candidate will need to demonstrate flexible teamworking and a tenacious approach to delivering structural solution outputs to projects. Excellent oral and written communication skills and the ability to translate structural knowledge to a meaningful output for multidisciplinary project teams are highly desirable qualities for this position. *Responsibilities* • Lead the protein crystallography team and provide protein crystallography support for research projects • Maintain a strategic overview of projects requiring structural biology support; engage and communicate effectively with stakeholders to ensure optimal use of resources • Guide molecular biology and protein purification for crystallography • Carry out crystallization, x-ray data collection, structure determination and refinement of proteins and protein-ligand complexes • Communicate results to chemists, computational chemists and cross-disciplinary project teams so that results make an impact in structure-based design and understanding of SAR of new leads • Develop and maintain high quality standards for in-house structure data and crystallographic computing procedures • Responsible for organization of own and team's laboratory work including ordering laboratory supplies and equipment • Formal and informal teaching and coaching of other lab staff and trainees *Experience required* • PhD in macromolecular crystallography/structural biology plus 5 years industry experience or equivalent • Demonstrated experience in protein crystallization, structure determination, refinement and validation • Knowledge of chemistry, molecular structure and protein-ligand interactions • Knowledge of software for protein structure solution and refinement • Knowledge of protein production *About Syngenta* Syngenta is one of the world’s leading companies with more than 27.000 employees in over 90 countries dedicated to our purpose: Bringing plant potential to life. Through world-class science, global reach and commitment to our customers we help to increase crop productivity, protect the environment and improve health and quality of life. For more information about us please go to http://www.syngenta.com/. For a full job profile and to apply to this position, please visit http://www.syngentajobs.com/Taleo_apply.html?CountryCode=2gblang=enlocation=23236270036668portal=101430233 - job number 14006122 Application deadline is 16th June. I am happy to answer informal questions about the position (please use the e-mail address below), but if you wish to apply you must go through the Syngenta Jobs website linked above. Thanks, Daniel Kloer Head of Protein Analysis and Computational Chemistry Syngenta daniel.kl...@syngenta.com
[ccp4bb] Protein scientist position at Syngenta
Protein Scientist £28,000 - £35,000 + benefits Jealott’s Hill, Bracknell, Berkshire As an independent worker, you will be a part of our Protein Production Team, providing protein expression/purification support in a timely manner across a range of Crop Protection Research projects. This will involve carrying out small to medium-scale protein purification and delivering purified proteins for assays and crystallography and communicating results to the project team to influence/guide project decisions. You will also have the opportunity to conduct expression screening in E.coli (essential), insects and yeast (desirable), as well as purifying and characterising difficult to express proteins in heterologous systems with genes from a variety of sources. With a BSc/PhD in protein biochemistry and or relevant lab experience you will have the skills in isolating proteins from complex mixtures, both native and recombinant sources. Experience in working with membrane protein and kinases would be highly advantageous. Bioinformatics skills to analyse DNA and protein data and the ability to deal with academic and industrial collaborators, including CROs, are also desirable. You should also have the ability to learn quickly and apply new skills with excellent organisational skills. To apply online, please visit www.syngenta.com and navigate to our current vacancies via the career page. Closing date: 1st July 2011. Syngenta is one of the world's leading companies with more than 26,000 employees in over 90 countries dedicated to our purpose: Bringing plant potential to life. Through world-class science, global reach and commitment to our customers we help to increase crop productivity, protect the environment and improve health and quality of life. For more information about us please go to www.syngenta.com
[ccp4bb] Position available at Syngenta
Protein Crystallographer Jealott's Hill, Bracknell, Berkshire, UK We are looking for a postdoctoral fellow with a PhD in biochemistry or equivalent who is enthusiastic about working across the range of protein crystallography activities, from protein production to structure refinement of proteins and protein-ligand complexes. The qualified candidate will have a strong background in protein production and crystallisation as well as x-ray data collection, structure refinement and validation. Computational and molecular modelling skills are a plus. Candidates will need to demonstrate flexible teamworking and a tenacious approach to delivering structural solution outputs to projects. Excellent communication skills and the ability to translate structural knowledge to a meaningful output for multidisciplinary project teams are highly desirable qualities for this post. Syngenta is a world-leading agribusiness committed to sustainable agriculture through innovative research and technology. The company is a leader in crop protection, and ranks third in the high-value commercial seeds market. Sales in 2010 were approximately $11 billion. Syngenta employs over 26,000 people in more than 90 countries. Syngenta is listed on the Swiss Stock Exchange (SYNN) and on the New York Stock Exchange (SYT). Jealott's Hill International Research Centre is the largest research and technology site within the company. Further information is available at www.syngenta.com. If you are excited by the prospect of developing your career with a world-leading agribusiness, we would like to hear from you. The post is expected to be for two years. The successful candidate will be employed by SRG and placed at Syngenta, Bracknell. Please visit http://www.srg.co.uk/syngentajobs.aspx to apply online. Informal enquiries can be made to Daniel Kloer (daniel.kl...@syngenta.com).
