[ccp4bb] Postdoctoral position in time-resolved EM at the University of Leeds

[Stephen Muench]

Dear All,
A BBSRC funded postdoctoral position is available to become 
part of an international team working on new methodologies for time resolved 
single particle cryo-EM allowing us to trap different conformational states of 
proteins and protein complexes in the µs-ms timeframe. The project will be led 
by the Muench group at the University of Leeds and will involve collaborations 
with Prof Howard White (Eastern Virginia Medical School) and Prof Martin 
Trebbin (Hamburg University centre for ultrafast imaging). This will bring 
together the world class EM facilities in the Leeds Astbury Biostructure 
facility, including two Titan Krios microscopes and the cutting-edge technology 
from the microfluidics field in Hamburg. The successful candidate will work 
between Leeds and Hamburg adapting the microfluidic technology developed in the 
Trebbin group and installing it within the current setup in Leeds. This project 
will build on the significant recent advances in the EM field and previous 
experience in developing time-resolved electron microscopy approaches to 
develop a novel system that can trap conformational states in the µs-ms 
timeframe. This would be an excellent opportunity for someone looking to pursue 
the latest developments in EM and someone who may wish to develop their own 
independent research utilizing this new technology. 

Closing Date: 23 June 2017.

For further details please contact s.p.mue...@leeds.ac.uk  and/or visit the 
following link http://jobs.leeds.ac.uk/FBSBM1065

Best wishes,

Ste

[ccp4bb] PhD Studentship in Crystallography at the University of leeds

[Stephen Muench]

Dear all,

 Applications are invited for an EPSRC CASE award in membrane protein 
crystallography and electron microscopy. 

This PhD, funded by Pfizer Neusentis and an EPSRC CASE award, will use a 
multidisciplinary approach to study membrane ion channels important for human 
health and disease. This project will primarily be focused on X-ray 
crystallography and will take advantage of the recent £900,000 upgrade to the 
crystallization facility at the University of Leeds. In addition, single 
particle cryo electron microscopy will also be used, where appropriate, to 
obtain mechanistic information using new technologies developed at Leeds. The 
structural and mechanistic information obtained will lead into a structure 
based inhibitor design program. This project will allow the successful 
candidate to work in a multi-disciplinary field using cutting edge 
technologies. 

The demanding nature of this project means we are seeking highly motivated Ph.D 
candidates with an M.Sc./Bsc in biochemistry, molecular biology or a related 
discipline and a strong interest in structure-function studies on proteins. 
Experience of protein overexpression, purification, crystallization or membrane 
proteins is desirable but not essential. For informal enquiries and more 
details please contact Dr Stephen Muench (s.p.mue...@leeds.ac.uk), Dr Jonathan 
Lippiat ( j.d.lipp...@leeds.ac.uk ) or Prof. Adrian Goldman 
(a.gold...@leeds.ac.uk). 

For applications please visit; 
https://studentservices.leeds.ac.uk/pls/banprod/bwskalog_uol.P_DispLoginNon


Applicants must have an undergraduate- (minimum of 2:1, or equivalent) or 
masters-level degree in a related subject and must be UK or EU citizens (EU 
citizens must of resided within the UK for a minimum of 3 years to be eligible 
for the full stipend). The position will start in October 2014 and the closing 
date for applications will be 6th June.

Best wishes,

Stephen



Dr Stephen Muench
School of Biomedical Sciences
University of Leeds
Leeds
LS2 9JT
+44(0) 113 3434279