A postdoctoral position is available on a multidisciplinary project between the 
group of Prof Littlechild at the Henry Wellcome Building for Biocatalysis and 
Prof Frank Volmer in Physics within the new LSI Building in association with 
the Physics Department. The aim is  to study enzyme structure, stability and 
mechanism, and enzyme folding with state-of the art methodologies including 
single-molecule optical nanosensors, X-rays, and molecular dynamics 
simulations. This project will be part of the UKRI Molecular Mechanics 
Initiative at the University of Exeter which is a cutting-edge research 
programme that aims to achieve breakthroughs in how to detect, analyse, and 
manipulate molecules at the ultimate single-molecule level.
Experience with gene cloning and over-expression, enzyme purification, X-ray 
structural analysis, mutational analysis and application of other biophysical 
techniques is required. Familiarity with surface immobilisation of proteins and 
enzymes, molecular dynamics simulations, Raman and SERS protein analysis, and 
electrochemical sensors is desirable.
The successful candidate can be appointed as Postdoctoral Research Fellow 
(Grade F) depending on the skills and experience the individual can bring to 
the role.
Postdoctoral Research Fellow on Grade F from £35,211 up to £39,609 per annum. 
Please find further job specifications on the Exeter web site and any 
interested candidates should apply by the closing date of 28th May. For further 
information, please contact Prof J Littlechild, email 
j.a.littlech...@exeter.ac.uk, or telephone (01392) 7223468.





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