[ccp4bb] Cavity is waiting unknown ligand

Dear All, I have inside cavity in my protein structure with some conserved residues. We do not know function or ligand for that domain. How I could find ligand candidates which fit to this cavity? Maybe somehow with pdbe? Thank you, Heidi

[ccp4bb] Alternative conformation in Mac Refmac5

except R-factors are some higher. Do I have some problem or is there bug in Mac version of Refmac5.5.0102? How problem could be solved? Thank you, Heidi Tuominen University of Turku, Finland