Becky, I am a "guest" on this list and normally don't check it, but I did today. After reading your post, I went to see the PDR blurb on Gleevec to see if there might be any chance an idea I have might have any validity.
A few months ago as an adjunct to my research in autism, I started an internet list for those who have trouble with absorbing too much oxalate from food, leading to oxalates collecting in odd tissues around the body. Oxalates seem to be causing a lot of GI problems in children with autism, and the low oxalate diet is helping some neurological issues in them, which is why I started that list. Nevertheless, it is just a general list for those trying to reduce dietary oxalates. Most doctors are only aware of oxalates being an issue in people who develop kidney stones, but many people in many fields have found that oxalates associate with a lot of conditions, and if they are behind a problem then lowering their quantity in the diet can have a big impact. Oxalates bind calcium, so where "lesions" show up with calcium oxalate, sometimes the tissue looks white which is why your description caught my eye. On the chance that something about Gleevec might give you a "leaky gut", you might absorb more oxalates from food than usual, and that might mean your tissues would get more exposure to oxalate, which likes to bind calcium. Of course, I have no idea if this could be related, but a lot of the other side-effects of Gleevec do seem to associate with oxalate issues sometimes, like diarrhea, headaches, nausea, rashes, etc. Lots of things produce these symptoms, so I'm not sure I'm on track but how would we tell if I were? Usually, most people do not absorb but 2 or 3% of oxalates from food, but changes in the gut can make you absorb a whole lot more.. If there is any validity to the idea that oxalates are related to these mouth sores, then maybe these symptoms would come and go in relationship to whether you were or were not eating high oxalate foods. For a list of high oxalate foods, see this list: http://www.branwen.com/rowan/oxalate.htm There are many other similar listings on the internet. Again, if this has any validity, you will probably figure it out by just watching if the sores come and go in relationship to the oxalate content of what you eat. I hope it could be this simple! I wouldn't have said a word except that it sounds like the doctors have no theories at all, and maybe having this one to test is a baby step ahead. Susan Owens ([EMAIL PROTECTED]) At 03:25 PM 11/24/2005 +0000, you wrote: >Michael, > >I also get mouth sores in response to gleevec, although mine is >somewhat different than yours. Mine primarily affects the edges of >my tongue and the insides of my cheeks. It causes whitened areas >under the skin. This side effect has been gradually decreasing with >time ( started taking gleevec in April 2005 at 400 mg, increasing to >800 mg in June 2005). The soreness became worse with the dose >increase. When it first appeared, I took 2 courses of Diflucan in >the event that it was Oral Thrush (an oral yeast infection) which >does occur periodically in chemotherapy patients. However, the >Diflucan didn't help. Some CML list members gave me some helpful >suggestions. I found that using Tom's Natural toothpaste, and using >Biotene Dry Mouth mouthwash were helpful to decrease the burning >associated with brushing my teeth. I understand that there is >something called "magic mouthwash" that can be helpful as a kind of >a swish and spit treatment to help numb your mouth a little if you >are having trouble eating, however, I can't really vouch for that >either way as I didn't try it. Your oncologist or dentist can >probably call a prescription for the magic mouthwash in to your >phamacist if you want to give it a try. My oncologist didn't know >know what about it, but my dentist and pharmacist did. The problem >has gradually diminished to the point where it is barely noticeable >now. Hang in there, hopefully time will help you too! How long have >you been on gleevec? How long have you had the mouth sores? What >is your gleevec dosage? > >Becky Bensenhaver > > > > > > >New! Sign up for local CML support group meetings in your local community >at http://cml.meetup.com > >Apply for Commercial Real Estate loans online and submit your deal to >dozens of hungry lenders in just minutes. Loan programs for all types of >business and commercial real estate. 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