Quick update - upstream was very happy to see a first bunch of patches and
created
https://github.com/GENtle-persons/gentle-m
with membership to GENtle-persons initially offered to Andreas and myself (I
already accepted).
So, I think my next steps are to transfer d/patches/* to an upstream dev branch
and then sync with upstream about a new point release.
Best,
Steffen
> Gesendet: Montag, 31. Juli 2023 um 12:39 Uhr
> Von: "Steffen Möller"
> An: "Med Team"
> Betreff: GENtle - some progress
>
> Hello,
>
> I just uploaded another iteration of GENtle to our servers. It has some
> quirks, still, as in that wxWidgets' runtime checks kick in with the one or
> other window that is opened, something about the windows parents not set
> right, but I guess this is usable. I'll finish this up over the next weeks.
>
> Some background, GENtle comes from a time when the cloning of DNA (as in: get
> some large string of unknown DNA of interest connected in a much larger piece
> of well-known DNA that can be multiplied by bacteria) was a precondition to
> get that DNA sequenced. With technological advancements that has mostly been
> substituted with "let us just sequence the whole organism". And there is
> software like https://www.snapgene.com/ doing many things right that come to
> a rescue for smaller groups and/or smaller projects, and for all the many
> tasks like amplifying the gene product of what was cloned (as in producing
> insulin, see https://openinsulin.org/).
>
> IMHO times have changed again in that we already have sequenced of what we
> want to see sequenced and now the research community shifted from "get DNA
> out from human cells" to "get DNA into (typically cultures of) human cells".
> To move any gene across the cell wall, you need a special kind of vehicle,
> and technically those look just like those plasmids that GENtle already knows
> how to design. So this is not just some old outdated technology lurking with
> us, we should just think about how we can modernize the GUI a bit and maybe
> add some public data.
>
> I'll discuss data to be added with my wet-lab colleagues, also some
> imperfections in software may be ideal as student projects to
> describe/fix/learn, will see.
>
> Best,
> Steffen
>
>