Re: [FRIAM] saRNA

2023-09-10 Thread David Eric Smith
Yeah. My first thought on looking at this was that getting the dosing right is going to be a bear. Now you not only have to deal with variation among people in mRNA expression levels, but you have to manage variation in the amplifier by an RDRP (RNA-dependent RNA polymerase). My thoughts

Re: [FRIAM] saRNA

2023-09-10 Thread Steve Smith
The space between */Scylla and Charybdis/ *seems to be shrinking by halves.   On the one had the conspiracists are "awfulizing" everything while others might be "normalizing" everything in the spirit of (polyanna?) progress? With what *appears* to be a sharp rise in auto-immune disorders in

[FRIAM] saRNA

2023-09-09 Thread glen
https://sciencebasedmedicine.org/self-amplifying-rna-vaccines/?utm_source=rss_medium=rss_campaign=self-amplifying-rna-vaccines "It is also likely that there will be another round of fear-mongering about the new technology. It probably best for scientists to get ahead of this, to introduce and