[NMusers] Ambiguous independence of independent variable.

Hi nonmem users! I have troubles explaining to statisticians (and perhaps to myself) why it can be OK to model data where the dose is adjusted based on the dependent variable, and wonder if I could get some help. This is a very relevant issue when planing for adaptive designs where the dose is

SV: [NMusers] Ambiguous independence of independent variable.

Hi Matts, I agree on your conclusions and think the issue of missing data is a very similar problem. There the missing completely at random and missing at random would match your examples a and b. For missing data there exists litterature and also perhaps a better understanding among