Dear Nathalie
In answer to your question; yes, it is usual to see this "unstability" in
the final few iteration OFVs.
When using the IMP method, I often include two sequential $EST commands. The
first command will perform optimisation of parameter estimates until a
global minimum is found.
Dear all,
I would like to share with you and get people's opinions on a recent issue I
had.
I have a data set of 46 patients, orally dosed, with very dense sampling
during absorption (0.25h, 0.5h, 0.75h, 1h, 1.5h, 2h, 3h, 4h, 6h, 8h, 12h,
24h, 36h), Cmax at around 4 hours.
During modelling,
Dear all,
I have a problem regarding delay differential equations (DDEs) in NONMEM. So
far, I have been unable to find a way of successfully using DDEs in NONMEM,
due to there being no in-built DDE solver (as far as I know). To me, it
seems that the problem is that there is no way of recalling
