...@globomaxnm.com] On
Behalf Of Mark Sale
Sent: 11 November 2016 14:24
To: Mats Karlsson; Gewitz, Andrew
Cc: nmusers@globomaxnm.com
Subject: Re: [NMusers] $PRIOR with normal for OMEGA?
thanks Mats,
I've never had much luck getting TNPRI to work, pretty limited examples in
the docs. I actually
nt: Thursday, November 10, 2016 11:36:13 PM
To: Gewitz, Andrew; Mark Sale
Cc: nmusers@globomaxnm.com
Subject: RE: [NMusers] $PRIOR with normal for OMEGA?
Hi Mark,
As I'm sure you know NONMEM has the TNPRI functionality for that. If you want
to use it without the TNPRI functionality, you can es
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On
Behalf Of Martin Bergstrand
Sent: den 11 november 2016 08:32
To: Mark Sale <ms...@nuventra.com>
Cc: nmusers@globomaxnm.com
Subject: Re: [NMusers] $PRIOR with normal for OMEGA?
Hi Mark,
Not sure about this but how
Hi Mark,
Indeed there is: As an alternative to NWPRI, there is the TNPRI subroutine that
you can use with $PRIOR (frequentist prior).
This functionality is tripple normal, with regards to thetas, omegas and
sigma(s).
I will describe this more in detail than Mark would need (hopefully for the
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On
Behalf Of Gewitz, Andrew
Sent: Friday, November 11, 2016 6:53 AM
To: Mark Sale
Cc: nmusers@globomaxnm.com
Subject: Re: [NMusers] $PRIOR with normal for OMEGA?
Mark,
Without getting too technical, recall that the inverse w
Hi Mark,
Not sure about this but how about estimating THETAS scaling fix OMEGAs (e.g. CL
= THETA(1)*EXP(THETA(2)*ETA(1)) ; $OMEGA 1 fix)? Then you can implement the
prior in the same way for random effect parameters as you do for fixed effect
parameters.
Ps. Probably not be compatible with
Mark,
Without getting too technical, recall that the inverse wishart is a
distribution on matrices, and is naturally conjugate to the multivariate normal
distribution (i.e. on vectors of random variables.) Generally, this is chosen
because posterior computations are simplified and it is easy
Is it possible to use a normal prior for OMEGA? The default is inverse Wishart,
but I'd be interested in using Normal (insuring that it is positive definite)
Any ideas?
thanks
Mark Sale M.D.
Vice President, Modeling and Simulation
Nuventra Pharma Sciences, Inc.
2525 Meridian Parkway, Suite
