Dear all,
Thank you very much for clarifying my doubts and giving me some lights. I'm
going to keep it in mind.
Regards, Niurys
MSc Niurys de Castro Suárez
Assistant Professor of Pharmacometrics
Assistant Research
Pharmacy Department
Institute of Pharmacy and Food,
University of Havana
Cuba
El
Thanks Niurys for revisiting this.
It was discussed quite a lot before.
Using T in $DES, as Paolo suggested, is what I always do.
As far as your code / model file is concerned, I somehow like it as long as
you will be able to explain in simpler terms to non-pharmacometricians and
Physicians what
PK block is executed only once per record so CL(TIME) is constant
between records, while in the DES block T (time) changes continuously,
thus implementing time dependence CL(T) exactly rather than
approximately. The rest is fine.
Thanks
Leonid
On 7/22/2021 4:19 PM, Niurys.CS wrote:
Dear
Dear Niurys,
I have not checked the whole code, but something I spotted as incorrect is the
use of TIME.
The variable TIME only changes in a discrete way with the time of events in the
dataset (e.g. doses or samples).
If you want something truly "continuous" you need to use the variable T and
Dear Leonid,
Thanks for yor suggestion. I've never thought in that possibility.
However, I have two questions:
1-Why must I write those equations inside $DES?
2-Do you think the ODE that I proposed are Ok?
Thank you very much
MSc Niurys de Castro Suárez
Assistant Professor of Pharmacometrics
Definition of CL should be moved inside the DES block; other than that,
looks fine:
; DES --
$DES
CL2_TIME = CL2*EXP(-KDES*T)
CL_TOTAL = CL2_TIME + CL1 ; total clearance
...
Thanks
Leonid
On 7/22/2021 3:30 PM, Niurys.CS wrote:
Dear nmusers,
I'm working on the pharmacokinetics of an
