[NMusers] 18th Annual Scientific Meeting PAGANZ 2017 Feb 6th - 8th Adelaide Australia - Registrations and abstracts open

Dear Colleagues, We are pleased to announce the next PAGANZ scientific meeting to be held in Adelaide, Australia, 6th to 8th February 2017. Registration and call for abstracts is now open. Please visit the PAGANZ home page for details and links to registration for the meeting:

[NMusers] $PRIOR with normal for OMEGA?

Is it possible to use a normal prior for OMEGA? The default is inverse Wishart, but I'd be interested in using Normal (insuring that it is positive definite) Any ideas? thanks Mark Sale M.D. Vice President, Modeling and Simulation Nuventra Pharma Sciences, Inc. 2525 Meridian Parkway, Suite

Re: [NMusers] $PRIOR with normal for OMEGA?

Mark, Without getting too technical, recall that the inverse wishart is a distribution on matrices, and is naturally conjugate to the multivariate normal distribution (i.e. on vectors of random variables.) Generally, this is chosen because posterior computations are simplified and it is easy

Re: [NMusers] $PRIOR with normal for OMEGA?

Hi Mark, Not sure about this but how about estimating THETAS scaling fix OMEGAs (e.g. CL = THETA(1)*EXP(THETA(2)*ETA(1)) ; $OMEGA 1 fix)? Then you can implement the prior in the same way for random effect parameters as you do for fixed effect parameters. Ps. Probably not be compatible with

[NMusers] Mango Solutions 2017 UK & Central Europe Public training courses -Rfor PK, Clinical Trial Simulation in R & Clinical Trial Graphics in ggplot2

Hi Everyone, Mango Solutions are providing the following public R training courses for 2017 in the UK and Central Europe. These courses have been carefully created & developed over the last decade to remain current and applicable specifically for the Pharmaceutical sector. Course titles,

[NMusers] 9th PMX Network Benelux meeting - Final program

Dear Colleagues, We are happy to invite you to the 9th meeting of Pharmacometrics Network Benelux. Please mark the following date and time in your agenda: When: Thursday, November 24th 2016 - 12:00 - 18:00 Where: hosted by Ablynx NV, Belgium Technologiepark, 21 9052 Gent/Zwijnaarde Agenda

[NMusers] SAVE the DATES!!!! NONMEM/PDxPoP workshops for 2017 presented by ICON

Please save the dates! Below is a list of the workshops that we plan to present in 2017! April 3-day NONMEM/PDxPoP Workshop - April 4-6, 2017 - Howard County, Maryland - Business Training Center June 1-day Advanced Methods of NONMEM - June 5, 2017 - PAGE Conference - Budapest, Hungary

RE: [NMusers] Estimation method using ITS and IMP iterations

Dear Nathalie In answer to your question; yes, it is usual to see this "unstability" in the final few iteration OFVs. When using the IMP method, I often include two sequential $EST commands. The first command will perform optimisation of parameter estimates until a global minimum is found.