One problem I am aware if you are using the ESXi appliance
resulting in very slow bootup, extreme high CPU load and even data
corruption:
If you are on ESXi 5.5, you must use the vmxnet3 vnic
or disable TCP segmentation offload in e1000.conf; add the following and
reboot
hi Eugen
beside the ESXi appliance, napp-it does not modify
any system setting (you can even disable napp-it without problems)
so this must be a maybe simulanious but different problem.
In your logs are controller and multipath errors so I would check
iostat, zpool status and format behaviours.