http://www.reuters.com/newsArticle.jhtml?type=healthNews&storyID=8216894
Traditional Medicine Derivatives Kill Cancer Cells Mon Apr 18, 2005 05:46 PM ET NEW YORK (Reuters Health) - Compounds derived from indirubin, a component of a Chinese herbal medicine, can cause human cancer cells to self-destruct, researchers have shown. A traditional Chinese medicine, Danggui Longhui Wan, is used to treat leukemia. In previous experiments, the active ingredient indirubin has seen to kill cells by blocking an enzyme called CDK and thus interrupting the normal cell cycle. Now, Dr. Richard Jove, from the Moffitt Cancer Center and Research Institute in Tampa, Florida, and colleagues report in the Proceedings of the National Academy of Sciences on another way that derivatives of the indirubin kill cancer cells. The researchers discovered that the compounds induce breast and prostate cancer cells to shut down and die by inhibiting a signaling pathway, known as Src-Stat3. "These findings provide evidence of another mechanism for indirubin's antitumor activity," Jove's group writes. One of the derivatives, designated E804, was particularly potent in destroying cancer cells and "has potential as an antitumor therapeutic agent in epithelial malignancies," the team concludes. SOURCE: Proceedings of the National Academy of Sciences, April 18, 2005. ------------------------ Yahoo! Groups Sponsor --------------------~--> DonorsChoose. A simple way to provide underprivileged children resources often lacking in public schools. Fund a student project in NYC/NC today! http://us.click.yahoo.com/EHLuJD/.WnJAA/cUmLAA/TySplB/TM --------------------------------------------------------------------~-> -------------------------- Want to discuss this topic? Head on over to our discussion list, [EMAIL PROTECTED] -------------------------- Brooks Isoldi, editor [EMAIL PROTECTED] http://www.intellnet.org Post message: osint@yahoogroups.com Subscribe: [EMAIL PROTECTED] Unsubscribe: [EMAIL PROTECTED] *** FAIR USE NOTICE. This message contains copyrighted material whose use has not been specifically authorized by the copyright owner. OSINT, as a part of The Intelligence Network, is making it available without profit to OSINT YahooGroups members who have expressed a prior interest in receiving the included information in their efforts to advance the understanding of intelligence and law enforcement organizations, their activities, methods, techniques, human rights, civil liberties, social justice and other intelligence related issues, for non-profit research and educational purposes only. We believe that this constitutes a 'fair use' of the copyrighted material as provided for in section 107 of the U.S. Copyright Law. If you wish to use this copyrighted material for purposes of your own that go beyond 'fair use,' you must obtain permission from the copyright owner. For more information go to: http://www.law.cornell.edu/uscode/17/107.shtml Yahoo! Groups Links <*> To visit your group on the web, go to: http://groups.yahoo.com/group/osint/ <*> To unsubscribe from this group, send an email to: [EMAIL PROTECTED] <*> Your use of Yahoo! Groups is subject to: http://docs.yahoo.com/info/terms/
