dcemri 0.10 has been released on CRAN
"dcemri" is (to the best of my knowledge) the first public-domain software
package for the quantitative analysis of dynamic contrast-enhanced MRI
(DCE-MRI) and diffusion-weighted MRI (DW-MRI or DWI). Data import and
export is availble for ANALYZE or NIfTI data formats (sorry, no DICOM).
Images are stored in neurological format regardless of the "handedness" of
the data; i.e., simple reflections are allowed via the q-form or s-form
codes in NIfTI.
Software development is currently under SourceForge via
http://www.dcemri.org
A mailing list has been established and feedback is appreciated.
Functionality includes:
Motion correction and co-registration via "fast template matching"
T1 quantification via multiple flip-angle acquistions (inversion recovery
coming soon!)
Conversion to gadolinium contrast agent concentration
Parametric models for the arterial input function (AIF), both
literature-based (Tofts-Kermode and Fritz-Hansen) and data-adaptive.
Kinetic parameter estimation using a variety of compartmental models
(e.g., Kety, extended Kety, etc.)
Estimation via nonlinear regression (Levenburg-Marquardt optimization) or
Bayesian methods (MCMC)
Semi-parametric methods via Bayesian P-splines (MCMC)
A detailed vignette has been included as a "tutorial" for the package and
permission was obtained to include the simulated data from Buckley (2002;
MRM). Basic NIfTI data sets have also been provided.
Sincerely,
Brandon
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