Re: [R] Use of R in clinical trials

2010-02-23 Thread Emmanuel Charpentier
Le samedi 20 février 2010 à 09:44 -0800, Dieter Menne a écrit : If you check http://n4.nabble.com/R-help-f789696.html you will note that this thread has the largest number of read since years. Looks like an encouragement to Mark to keep the mentioned CRAN document updated. To add a

Re: [R] Use of R in clinical trials

2010-02-23 Thread Dieter Menne
: http://n4.nabble.com/Use-of-R-in-clinical-trials-tp1559402p1565708.html Sent from the R help mailing list archive at Nabble.com. [[alternative HTML version deleted]] __ R-help@r-project.org mailing list https://stat.ethz.ch/mailman/listinfo/r

Re: [R] Use of R in clinical trials

2010-02-21 Thread Dieter Menne
(with caveats) in statistics. Dieter -- View this message in context: http://n4.nabble.com/Use-of-R-in-clinical-trials-tp1559402p1563402.html Sent from the R help mailing list archive at Nabble.com. __ R-help@r-project.org mailing list https://stat.ethz.ch

Re: [R] Use of R in clinical trials

2010-02-21 Thread Kingsford Jones
Message- From: Christopher W. Ryan cr...@binghamton.edu Sent: Feb 18, 2010 1:08 PM To: r-help@r-project.org Cc: p.dalga...@biostat.ku.dk Subject: Re: [R] Use of R in clinical trials Pure Food and Drug Act: 1906 FDA: 1930s founding of SAS: early 1970s (from the history websites of SAS

Re: [R] Use of R in clinical trials

2010-02-20 Thread Dieter Menne
mmHg My message: If you hear not validated or validated, question it. Dieter -- View this message in context: http://n4.nabble.com/Use-of-R-in-clinical-trials-tp1559402p1562982.html Sent from the R help mailing list archive at Nabble.com

Re: [R] Use of R in clinical trials

2010-02-19 Thread Dieter Menne
the integration into the existing clinical database systems that would have to be rewritten **and validated**. Implicitly: Even if you let your cat enter SAS code, the results are correct, because they SAS is validated. Dieter -- View this message in context: http://n4.nabble.com/Use-of-R

Re: [R] Use of R in clinical trials

2010-02-19 Thread John Sorkin
-of-R-in-clinical-trials-tp1559402p1561317.html Sent from the R help mailing list archive at Nabble.com. __ R-help@r-project.org mailing list https://stat.ethz.ch/mailman/listinfo/r-help PLEASE do read the posting guide http://www.R-project.org/posting

Re: [R] Use of R in clinical trials

2010-02-19 Thread Marc Schwartz
On Feb 19, 2010, at 6:56 AM, John Sorkin wrote: Bert, There is a lesson here. Just as intolerance of any statistical analysis program (or system) other than SAS should lead to our being drive crazy, so to should intolerance of any statistical analysis program (or system) other than R.

Re: [R] Use of R in clinical trials

2010-02-19 Thread Bert Gunter
: [R] Use of R in clinical trials Bert, There is a lesson here. Just as intolerance of any statistical analysis program (or system) other than SAS should lead to our being drive crazy, so to should intolerance of any statistical analysis program (or system) other than R. John Dieter Menne

Re: [R] Use of R in clinical trials

2010-02-19 Thread John Sorkin
marc_schwa...@me.com To: John Sorkin jsor...@grecc.umaryland.edu To: Gunter Bert gunter.ber...@gene.com Cc: Dieter Menne dieter.me...@menne-biomed.de Cc: r-help@r-project.org Sent: 2/19/2010 12:55:36 PM Subject: Re: [R] Use of R in clinical trials On Feb 19, 2010, at 6:56 AM, John Sorkin wrote

Re: [R] Use of R in clinical trials

2010-02-18 Thread Bill.Venables
Laboratories -Original Message- From: r-help-boun...@r-project.org [mailto:r-help-boun...@r-project.org] On Behalf Of Peter Dalgaard Sent: Thursday, 18 February 2010 5:55 PM To: Frank E Harrell Jr Cc: r-help@r-project.org; Cody Hamilton Subject: Re: [R] Use of R in clinical trials Frank E

Re: [R] Use of R in clinical trials

2010-02-18 Thread Liviu Andronic
On 2/18/10, Frank E Harrell Jr f.harr...@vanderbilt.edu wrote: How amazing that SAS is still used to produce reports that reviewers hate and that requires tedious low-level programming. R + LaTeX has it all over To simplify things, R + LyX could also be a solution. Liviu

Re: [R] Use of R in clinical trials

2010-02-18 Thread John Sorkin
...@gmail.com Cc: r-help@r-project.org To: Frank E Harrell Jr f.harr...@vanderbilt.edu Cc: Cody Hamilton cody.sh...@yahoo.com Sent: 2/18/2010 4:29:27 AM Subject: Re: [R] Use of R in clinical trials On 2/18/10, Frank E Harrell Jr f.harr...@vanderbilt.edu wrote: How amazing that SAS is still used to produce

Re: [R] Use of R in clinical trials

2010-02-18 Thread Barry Rowlingson
On Thu, Feb 18, 2010 at 12:12 PM, John Sorkin jsor...@grecc.umaryland.edu wrote: It is easy to devolve into visceral response mode, lose objectivity and slip into intolerance. R, S, S-Plus, SAS, PASW (nee SPSS), STATA, are all tools. Each has strengths and weaknesses. No one is inherently

Re: [R] Use of R in clinical trials

2010-02-18 Thread Frank E Harrell Jr
-project.org [mailto:r-help-boun...@r-project.org] On Behalf Of Peter Dalgaard Sent: Thursday, 18 February 2010 5:55 PM To: Frank E Harrell Jr Cc: r-help@r-project.org; Cody Hamilton Subject: Re: [R] Use of R in clinical trials Frank E Harrell Jr wrote: Cody, How amazing that SAS is still used to produce

Re: [R] Use of R in clinical trials

2010-02-18 Thread Peter Dalgaard
-boun...@r-project.org] On Behalf Of Peter Dalgaard Sent: Thursday, 18 February 2010 5:55 PM To: Frank E Harrell Jr Cc: r-help@r-project.org; Cody Hamilton Subject: Re: [R] Use of R in clinical trials Frank E Harrell Jr wrote: Cody, How amazing that SAS is still used to produce reports

Re: [R] Use of R in clinical trials

2010-02-18 Thread Bert Gunter
...@biostat.ku.dk Subject: Re: [R] Use of R in clinical trials I really like both of your responses. To add to Peter's thoughts, I've found that more than half of SAS programmers can learn modern programming languages given a push. And if pharmaceutical companies ever knew the true cost of SAS

Re: [R] Use of R in clinical trials

2010-02-18 Thread Frank E Harrell Jr
- From: r-help-boun...@r-project.org [mailto:r-help-boun...@r-project.org] On Behalf Of Frank E Harrell Jr Sent: Thursday, February 18, 2010 6:01 AM To: bill.venab...@csiro.au Cc: r-help@r-project.org; p.dalga...@biostat.ku.dk Subject: Re: [R] Use of R in clinical trials I really like both

Re: [R] Use of R in clinical trials

2010-02-18 Thread Christopher W. Ryan
Pure Food and Drug Act: 1906 FDA: 1930s founding of SAS: early 1970s (from the history websites of SAS and FDA) What did pharmaceutical companies use for data analysis before there was SAS? And was there much angst over the change to SAS from whatever was in use before? Or was there not

Re: [R] Use of R in clinical trials

2010-02-18 Thread Bert Gunter
-project.org] On Behalf Of Christopher W. Ryan Sent: Thursday, February 18, 2010 10:09 AM To: r-help@r-project.org Cc: p.dalga...@biostat.ku.dk Subject: Re: [R] Use of R in clinical trials Pure Food and Drug Act: 1906 FDA: 1930s founding of SAS: early 1970s (from the history websites of SAS and FDA

Re: [R] Use of R in clinical trials

2010-02-18 Thread Rolf Turner
On 19/02/2010, at 1:12 AM, John Sorkin wrote: It is easy to devolve into visceral response mode, lose objectivity and slip into intolerance. R, S, S-Plus, SAS, PASW (nee SPSS), STATA, are all tools. Each has strengths and weaknesses. No one is inherently better, or worse than the other.

Re: [R] Use of R in clinical trials

2010-02-18 Thread Douglas Bates
: p.dalga...@biostat.ku.dk Subject: Re: [R] Use of R in clinical trials Pure Food and Drug Act: 1906 FDA: 1930s founding of SAS: early 1970s (from the history websites of SAS and FDA) What did pharmaceutical companies use for data analysis before there was SAS? And was there much angst

Re: [R] Use of R in clinical trials

2010-02-18 Thread Peter Dalgaard
Christopher W. Ryan wrote: Pure Food and Drug Act: 1906 FDA: 1930s founding of SAS: early 1970s (from the history websites of SAS and FDA) What did pharmaceutical companies use for data analysis before there was SAS? And was there much angst over the change to SAS from whatever was in use

Re: [R] Use of R in clinical trials

2010-02-18 Thread Cody Hamilton
...@ccbr.umn.edu wrote: From: Erik Iverson er...@ccbr.umn.edu Subject: Re: [R] Use of R in clinical trials To: Frank E Harrell Jr f.harr...@vanderbilt.edu Cc: Cody Hamilton cody.sh...@yahoo.com, r-help@r-project.org Date: Wednesday, February 17, 2010, 9:05 PM Frank E Harrell Jr wrote: Cody, How

Re: [R] Use of R in clinical trials

2010-02-18 Thread Jeff Laake
I am old enough. Memory isn't always reliable but Doug Bates recounting is what I remember and a quick search has BMDP developed in 1961 and SAS in 1966. To my surprise, the search produced a site that offered BMDP for sale. On 2/18/2010 11:15 AM, Peter Dalgaard wrote: Christopher W. Ryan

Re: [R] Use of R in clinical trials

2010-02-18 Thread Bert Gunter
[mailto:r-help-boun...@r-project.org] On Behalf Of Jeff Laake Sent: Thursday, February 18, 2010 11:28 AM To: r-help@r-project.org Subject: Re: [R] Use of R in clinical trials I am old enough. Memory isn't always reliable but Doug Bates recounting is what I remember and a quick search has BMDP

Re: [R] Use of R in clinical trials

2010-02-18 Thread Peter Dalgaard
(Corrections/additional information welcome!) My recollection is that the BMD programs (which, in a later version, became BMDP) predated SAS and were specifically for BioMeDical analysis. How could I forget those! Yes, my old (as in 1980-1985) boss at the University hospital even had the

Re: [R] Use of R in clinical trials

2010-02-18 Thread Nordlund, Dan (DSHS/RDA)
-Original Message- From: r-help-boun...@r-project.org [mailto:r-help-boun...@r-project.org] On Behalf Of Peter Dalgaard Sent: Thursday, February 18, 2010 12:44 PM To: Douglas Bates Cc: r-help@r-project.org; Bert Gunter Subject: Re: [R] Use of R in clinical trials (Corrections

Re: [R] Use of R in clinical trials

2010-02-18 Thread Marc Schwartz
Subject: Re: [R] Use of R in clinical trials (Corrections/additional information welcome!) My recollection is that the BMD programs (which, in a later version, became BMDP) predated SAS and were specifically for BioMeDical analysis. How could I forget those! Yes, my old (as in 1980-1985

Re: [R] Use of R in clinical trials

2010-02-18 Thread Christopher W. Ryan
-project.org [mailto:r-help-boun...@r-project.org] On Behalf Of Peter Dalgaard Sent: Thursday, February 18, 2010 12:44 PM To: Douglas Bates Cc: r-help@r-project.org; Bert Gunter Subject: Re: [R] Use of R in clinical trials (Corrections/additional information welcome!) My recollection is that the BMD

Re: [R] Use of R in clinical trials

2010-02-18 Thread Marc Schwartz
On Feb 18, 2010, at 4:26 PM, Christopher W. Ryan wrote: Anyone have any recollection of Prophet software, from the National (US) Center for Research Resources? --Chris A quick Google search comes up with a very dated site at Northwestern:

Re: [R] Use of R in clinical trials

2010-02-18 Thread myrmail
] Use of R in clinical trials Pure Food and Drug Act: 1906 FDA: 1930s founding of SAS: early 1970s (from the history websites of SAS and FDA) What did pharmaceutical companies use for data analysis before there was SAS? And was there much angst over the change to SAS from whatever was in use before

[R] Use of R in clinical trials

2010-02-17 Thread Cody Hamilton
Dear all, There have been a variety of discussions on the R list regarding the use of R in clinical trials. The following post from the STATA list provides an interesting opinion regarding why SAS remains so popular in this arena: http://www.stata.com/statalist/archive/2008-01/msg00098.html

Re: [R] Use of R in clinical trials

2010-02-17 Thread Frank E Harrell Jr
trials for the pharmaceutical industry. Frank Cody Hamilton wrote: Dear all, There have been a variety of discussions on the R list regarding the use of R in clinical trials. The following post from the STATA list provides an interesting opinion regarding why SAS remains so popular

Re: [R] Use of R in clinical trials

2010-02-17 Thread Ista Zahn
for the pharmaceutical industry. Frank Cody Hamilton wrote: Dear all, There have been a variety of discussions on the R list regarding the use of R in clinical trials. The following post from the STATA list provides an interesting opinion regarding why SAS remains so popular

Re: [R] Use of R in clinical trials

2010-02-17 Thread Erik Iverson
Frank E Harrell Jr wrote: Cody, How amazing that SAS is still used to produce reports that reviewers hate and that requires tedious low-level programming. R + LaTeX has it all over that approach IMHO. We have used that combination very successfully for several data and safety monitoring

Re: [R] Use of R in clinical trials

2010-02-17 Thread Frank E Harrell Jr
Erik Iverson wrote: Frank E Harrell Jr wrote: Cody, How amazing that SAS is still used to produce reports that reviewers hate and that requires tedious low-level programming. R + LaTeX has it all over that approach IMHO. We have used that combination very successfully for several data and

Re: [R] Use of R in clinical trials

2010-02-17 Thread Peter Dalgaard
have the required skill set running around in circles. -pd Cody Hamilton wrote: Dear all, There have been a variety of discussions on the R list regarding the use of R in clinical trials. The following post from the STATA list provides an interesting opinion regarding why SAS remains so