Hello,
Substructure matching with SMARTS behaves strangely sometimes - see code below.
The pattern with [H] matches, but the pattern with [H,F] does not
(both should match).
from rdkit import Chem
mol=Chem.MolFromSmiles('Clc2sccc2[H]')
mol=Chem.AddHs(mol)
p1=Chem.MolFromSmarts('c2sccc2[H]')
p2=Chem.MolFromSmarts('c2sccc2[H,F]')
print(mol.HasSubstructMatch(p1))
print(mol.HasSubstructMatch(p2))
Best wishes,
Michal
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