Serum sickness <http://dermnetnz.org/reactions/serum-sickness.html>, due
to blood transfusion, viral infection or medicines (e.g. Ceclor^(TM));
urticaria is accompanied by fever, swollen lymph glands, painful joints
and nausea. It is thought to result from immune complexes of the
allergen and antibodies lodging in small blood vessels.
http://dermnetnz.org/reactions/urticaria.html
Transfused blood does, however, host a significant amount of
DNA-containing white blood cells, or leukocytes---around a billion cells
per unit (roughly one pint) of blood. Even blood components that have
been filtered to remove donor white cells can have millions of
leukocytes per unit.
http://www.scientificamerican.com/article.cfm?id=donor-blood-transfustion
But transfusions are not without their dangers. Among them is
transfusion-related acute lung injury (TRALI
<http://www.nursingcenter.com/prodev/ce_article.asp?tid=771975>), a rare
but potentially life-threatening condition that happens when there is a
clash between donor and recipient blood. TRALI is one of the major
causes of transfusion-association deaths in the developed world.
New research, recently published in the journal /Nature Medicine/
<http://dx.doi.org/10.1038/nm.2070>, suggests that many cases of TRALI
are due to a difference at just one genetic variation between donor and
recipient. This finding could someday enable screening before a
transfusion is done, allowing doctors to reduce the risk of TRALI.
One reason TRALI happens is that a donor's blood contains antibodies
that recognize something in the recipient's blood as an enemy. These
donor antibodies mount an attack that sets off a chain reaction of
immune responses in the recipient's body, leading to lung injury.
Several triggers for this type of TRALI have been identified. One of
these, the HNA-3 antigen, has repeatedly been associated with severe and
fatal TRALI reactions.
http://spittoon.23andme.com/2010/02/08/snpwatch-genetic-variant-involved-in-dangerous-blood-transfusion-reaction-identified/
In this investigation,
our preliminary findings on the occurrence of leishmanial
DNA in blood of FML-seroreactive healthy blood donors,
although corresponding to a relatively small number of samples,
are statistically significant. Taken together, these findings
lead to the conclusion that some form of screening is
advisable to decrease the risk of transmitting kala-azar by
blood transfusion, at least in endemic areas. Although most
blood banks test their blood donors for human immunodeficiency
virus and hepatitis virus, as well as for Chagas'
disease and syphilis (in India and Brazil, respectively), there
are several infectious agents for which routine screening is
not performed, including L. donovani, Toxoplasma gondii,
cytomegalovirus, and herpes simplex virus.5
http://www.ajtmh.org/cgi/reprint/62/1/128.pdf
http://lib.bioinfo.pl/meid:27845
On 25/06/2010 7:13 PM, Deborah Gerard wrote:
Has anyone ever heard of DNA conflight after a blood transfusion? This
person has developed colon cancer and wants to start on food grade
H202...can someone be kind enough to send me a personal e-mail of a
good source?
Thanks so much in advance,
Deb
