Hard to imagine how dynamically pinning irqhandlers to certain cpu's
would make a difference. But who knows. If the description of instance
types is correct the main differences between the two instance types
would be that m2 has more memory (7.5GB / 17.1 GB) but has only one
420GB virtual drive, while m1 has two of them. So m2 could run out of
cache for network IO less likely/often.

And apart from additional software, is there anything special in the
setup that differs from a stock m1.large or m2.xlarge guest?

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https://bugs.launchpad.net/bugs/1178707

Title:
  Kernel Panics - ec2

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