I've been having the same issue and am now waiting to see if purging
php5-apcu helps.

When apache stops responding, it has maxed out on threads and I get this
message in error.log:

[mpm_prefork:error] [pid 7628] AH00161: server reached MaxRequestWorkers
setting, consider raising the MaxRequestWorkers setting

I also have seen a apc related error:
PHP Warning:  apc_store(): GC cache entry 
'oc558dd98d33/AutoloaderOC_User_Interface' was on gc-list for 3602 seconds in 
/var/www/owncloud/lib/private/memcache/apc.php on line 21

Killing a few threads allowed me to get to /server-status on the server
which showed the threads were all in "Sending Reply" states responding
to owncloud/status.php requests.

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https://bugs.launchpad.net/bugs/1422484

Title:
  Apache hangs/crash while running OwnCloud 8.0.0

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