It looks like you are running a 32 bit version of 4D Server, and from a mounted 
volume instead of an actual location:
Quote: " Path:            /Volumes/VOLUME/*/4D Server 32-bit 
15.4.app/Contents/MacOS/4D Server"
^ I would suggest checking and making sure this is installed properly because 
the 'path' listed in the spindump looks like it may be a translocated path (I 
thought this was a feature of Sierra).

Also, 32 bit applications are limited to 4 Gigabytes of memory while 64 bit 
applications are limited to 16 Exabyte's of memory.

With 110 gb database and 150 users, I would guess you are hitting the 4 GB 
limit rather quickly because you likely have set the largest cache possible 
(2038 MB) which would set your memory footprint to about 3 GB on startup; then 
I would further guess that the normal usage from 150 users would likely eat up 
the remaining 1 GB of memory bringing the overall footprint up to 4 GB.

I suggest checking how much memory your application is using at the time of 
these issues. If it is close to 4 GB then this is why you are having issues.
http://kb.4d.com/assetid=77475

I think that the 64 bit version of 4D Server would be much better for a 110 gb 
database with about 150 users.

-Tim




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