Database size, Split to multiple instances or wait for version 6.1

[Conradt, Jeremy]

I have a TSM server currently running version 5.3.5 on Windows 2003 that
we plan to upgrade soon.  
The problem I have is our database has grown to 350 GB.  
The question I have is will version 6.1 of TSM be better capable of
maintaining a database this size and much larger or should I break it
apart?
I would rather keep everything together so we can make better use of
de-duplication that may be coming out with version 6.
Thanks,
Jeremy