You possibly already know this and are simplifying for the sake of
simplicity, but chemicals are not simply global environmental
settings.

Chemicals/hormones/peptides etc. are spatial concentration gradients
across the entire brain, which are much more difficult to emulate in
software then a singular concetration value. Add to this the fact that
some of these chemicals inhibit and promote others and you get
horrendously complex reaction diffusion systems.

:-) Yes, I was simplifying for the sake of my argument (trying not to cloud the issue with facts :-)

BUT your reminder is *very* useful since it's one of my biggest (explainable) complaints with the IBM folk who believe that they're going to successfully simulate the (mouse) brain with just simple and (in Modha's own words) cartoonish models of neurons (and I wish the Decade of the Mind people would hurry up and post the videos because there were several talks worth recommending -- including Dr. Modha's).

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