A new method of treatment of complex congenital heart disease A revolution in
medical Science
D.R. Baruah, FRCS Glas.
Dr. Dhani Ram Baruah Heart City & City of Human Genome
Sonapur, District : Kamrup, Assam. INIDIA.
e-mail:[EMAIL PROTECTED]
Abstract :
A complex congenital heart disease such as transposition of great arteries
(TGA) with or wihtout ASD or VSD, the common cause of blue babies is known to
all clinicians. The child borne with TGA without ASD or VSD and without having
patency of ductus aortus has incidence of survival of more than few hours,
which is very remote. Atrial septostomy was a standard procedure for long run
survival. Infusion of prostaglandin in used to keep the PDA patency as
short-term therapy, is also a standard medical practice before taking the
patient for corrective surgical procedure. Mustard procedure was a standard one
at atrial level, which was changed to senning procedure in different stage of
childhood. Switch surgical procedure had started some years ago and it is now a
standard surgical procedure of TGA and this should be done within 72 hours
after child is borne to obtain good results. However, late complications like
stenosis of pulmonary artery and aorta were
reported.
In conclusion the aim of surgical correction is to achieve physiological
corretion without which survival is very remote. Our revolutionary therapy
given with isolated plant organic compounds from additional plants fo
physiological correction with 100 percent success and survival is longer that
surgical correction without morbidity.
We have used a newly developed isolated plant organic compounds for an eleaven
year-old baby with TGA & VSD where signs and symptoms disappeared and child's
condition has improved clinically and behaving like a normal child. With this
discovery, the new ear of treatment of congenital anomalies with drugs isolated
from medicinal plants has started which is presented here.
Introduction :
Cyanosis of lips, finger nails, toes nails, breathlessness, chronic chest
infection with cough and cold and fever, retardation of mental and physical
growth, low exercise tolerance are the common features of TGA with VSD in late
days of childhood. These groups of patients do not usually survive beyond their
teenage as reported. At this stage, heart-lung transplant has become a standard
surgical procedure.
History :
Eleven-year-old girl was brought by parents with following congenital anomaly
to our clinic in month of July 2003. She attended another two hospitals where
she was sent home saying that there is no surgical or medical treatment
available at this stage.
The child had the following sings, symptoms and diagnosis
1. Ventricular septal defect (VSD)
2. TGA
3. Server PAH-right to left shunt
4. Congestion of both liver with impaired liver function
5. Loss of appetite
6. Frequent motions and unable to digest the food.
7. Stunted growth
8. Unable to concentrate on her studies
9. Exercise tolerance was poor and unable to play like a normal child.
10. Nail beds and lips were completely blue
11. Clubbing of toes and fingers present
12. Breathlessness on minimal exertion
13. Hemoglobin was 18 mg%
14. Colour echocardiography studies reveals VSD, servere PAH-VSD-8mm in size
with right to left shunt. Her parents were agreed to go for heart-lung
transplant using pig as a donor as our institute is pioneer in
xenotransplantation. However, as a first step, we have treated her with new
plant organic compounds and treatment was stated from July 5th 2003.
Results :
There days later, her chest infection and congestion began to disappear and
breathlessness was reduced. Blueness of lips, toes and fingernails began to
disappear and became pink.
Six day later, she regained her appetite and food intake was increased. We
continued the same treatment and on 29th July, post-treatment echo with colour
Doppler echocardiography was done.
The following findings were observed :
VSD was measured to be 8 mm in size and right to left shunt was changed to left
to right with normal ventricular function.
No pulmonary hypertension, which was reported earlier.
Hemoglobin was reduced by 3mg%
She could climb up the hill, she could ride bicycle without exertion.
Chest infection was disappeared. Heart size reduced by 1 cm. Lung fields was
clear. She puts on weight by 2.5 Kgs in 60 days.
Clubbing of toes and fingernails were completely disappeared. Hemoglobin was
reduced further to 12 mg%.
Echocardiography studies with colour Doppler in 60 days therapy, reveals that
there is no PAH. VSD remains with same diameter. Left to right shunt continues.
She has gone back to her school with unrestricted activities. She is continuing
the treatment with plant organic compounds and she is surviving without
heart-lung transplant.
Discussion :
Our organic compounds from medicinal plants have reduced the higher
pressure of morphological right ventricle which is functional left ventricle
allowing shunt to reverse where ratio of deoxygenated and oxygenated blood was
changed resulting disappearance of cyanosis, improvement of liver function and
exercise tolerance. Patients with complex congenital heart disease such as TGA
with VSD do not have incidence of long-term survival. They have a continuous
problems like chest infection, mental retardation, stunted growth, not doing
well in the school, breathlessness, and not gaining weight. Heart-lung
transplant is the only surgical procedure can be undertaken for these patients
with low incidence of survival. High Pulmonary pressure is the major problem.
Reduction of PA pressure with reversal of shunt are not known till today
treated with conventional therapy such as diuretics, digitalis. This is
probably for the first time treated successfully with
isolated plant organic compounds. However, long-term results are yet to be
seen with this therapy.
Three years later, we have reviewed her and found following changes.
1) Clubbing and cynosis completely disappeared.
2) Weight is increased by 6 kgs.
3) She has attended puberty normally.
4) She is doing well in school like other children.
5) Unrestricted exercises tolerence.
6) Total physiological correction of cardiopulmonary system.
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