Mice Breathing Bad Air Suffer Heart Disease - Study
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USA: December 21, 2005
 
CHICAGO - Breathing polluted air found in urban areas promotes heart
disease, especially when accompanied by a fatty diet, researchers who
tested the theory on mice said on Tuesday. 
 
The animal study was aimed at determining how air pollution --
specifically small airborne particles spewed by car exhaust and power
plants -- combined with a high-fat diet sped up the deterioration of the
body's cardiovascular system. 
"We established a causal link between air pollution and atherosclerosis,"
said the study's lead author, Lung Chi Chen of New York University's
School of Medicine. 

Airborne particles smaller than 2.5 microns across -- 1/40th the width of
a human hair -- are believed to penetrate deep into the lungs and damage
the body's cardiovascular system, exacerbating the buildup of plaque that
narrows arteries and makes them less flexible and prone to inflammation.
Such deterioration makes people ripe for a heart attack or stroke. 

Some estimates blame the tiny airborne particles from dust, soot and
smoke for 60,000 premature US deaths each year, according to the report
published in the Journal of the American Medical Association. 

In the six-month study, which was funded in part by the US Environmental
Protection Agency, 28 mice bred to be susceptible to cardiovascular
disease were divided into four groups. 

The mice that breathed air polluted with 15 micrograms per cubic meter of
small particulates -- comparable to the air quality in urban areas like
New York and within EPA limits -- fared worse than mice that breathed
clean, filtered air. 

The arteries of mice that breathed bad air and were fed a high-fat diet
were 42 percent blocked with plaque. Those that were fed a high-fat diet
but breathed clean, filtered air were 26 percent blocked. Blockages were
also apparent in mice fed a normal diet, with polluted air increasing the
amount of plaque. 

REUTERS NEWS SERVICE  
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