Hi,

When I want to compare two aligned sequences of the same length and find the mismatching positions, 'compareStrings' from the 'Biostrings' package seems to be the best choice. However, it does take into account any ambiguous matches (as matching any base to 'N'), as it can be found with the 'fixed' for 'matchPattern' and related functions. Would it be reasonable to include this, to ensure a consistent behavior of methods for 'XString' and related objects?

Best wishes
Julian

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