I would say it's much worse than mismatching class definitions.

https://github.com/Bioconductor/SummarizedExperiment/issues/16

-A

On 5/11/19 5:07 AM, Martin Morgan wrote:
I think it has to do with the use of reference classes in the assay slot, which 
have different environments

   se = SummarizedExperiment()
   saveRDS(se, fl <- tempfile())
   se1 = readRDS(fl)

and then

all.equal(se@assays, se1@assays)
[1] "Class definitions are not identical"
all.equal(se@[email protected], se1@[email protected])
[1] "Component \".self\": Class definitions are not identical"
se@[email protected]
<environment: 0x7fb1de1ede90>
se1@[email protected]
<environment: 0x7fb1fc2bca78>

Martin

On 5/11/19, 6:38 AM, "Bioc-devel on behalf of Laurent Gatto" 
<[email protected] on behalf of [email protected]> wrote:

     I would appreciate some background about the following:
> suppressPackageStartupMessages(library("SummarizedExperiment"))
     > set.seed(1L)
     > m <- matrix(rnorm(16), ncol = 4, dimnames = list(letters[1:4], 
LETTERS[1:4]))
     > rowdata <- DataFrame(X = 1:4, row.names = letters[1:4])
     > se1 <- SummarizedExperiment(m, rowData = rowdata)
     > se2 <- SummarizedExperiment(m, rowData = rowdata)
     > all.equal(se1, se2)
     [1] TRUE
But after serialising and reading se2, the two instances aren't equal any more: > saveRDS(se2, file = "se2.rds")
     > rm(se2)
     > se2 <- readRDS("se2.rds")
     > all.equal(se1, se2)
     [1] "Attributes: < Component “assays”: Class definitions are not identical 
>"
Session information provided below. Thank you in advance, Laurent R version 3.6.0 RC (2019-04-21 r76417)
     Platform: x86_64-pc-linux-gnu (64-bit)
     Running under: Ubuntu 18.04.2 LTS
Matrix products: default
     BLAS:   /usr/lib/x86_64-linux-gnu/libf77blas.so.3.10.3
     LAPACK: /usr/lib/x86_64-linux-gnu/atlas/liblapack.so.3.10.3
locale:
      [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C
      [3] LC_TIME=fr_FR.UTF-8        LC_COLLATE=en_US.UTF-8
      [5] LC_MONETARY=fr_FR.UTF-8    LC_MESSAGES=en_US.UTF-8
      [7] LC_PAPER=fr_FR.UTF-8       LC_NAME=C
      [9] LC_ADDRESS=C               LC_TELEPHONE=C
     [11] LC_MEASUREMENT=fr_FR.UTF-8 LC_IDENTIFICATION=C
attached base packages:
     [1] parallel  stats4    stats     graphics  grDevices utils     datasets
     [8] methods   base
other attached packages:
      [1] SummarizedExperiment_1.14.0 DelayedArray_0.10.0
      [3] BiocParallel_1.18.0         matrixStats_0.54.0
      [5] Biobase_2.44.0              GenomicRanges_1.36.0
      [7] GenomeInfoDb_1.20.0         IRanges_2.18.0
      [9] S4Vectors_0.22.0            BiocGenerics_0.30.0
loaded via a namespace (and not attached):
      [1] lattice_0.20-38        bitops_1.0-6           grid_3.6.0
      [4] zlibbioc_1.30.0        XVector_0.24.0         Matrix_1.2-17
      [7] tools_3.6.0            RCurl_1.95-4.12        compiler_3.6.0
     [10] GenomeInfoDbData_1.2.1
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