>There seems to be a general agreement that you get best results with
>calculating both the geometry optimization as well as the GIAO shifts on
>B3LYP/6-31G(d) level, but I trust whatever Henry suggests :-)
>With my own Gaussian calculations, I got excellent results for rigid and
>unpolar compounds, just as Barone suggested in his paper.
>


Dear all;  being off-line yesterday, I am picking up the thread here (which may
be  superceded by later posts).


The historical line might be of interest.  At the San Francisco  ASC,  I along
with about 500 people piled into the lecture given by  James La Clair;
subsequently about  3 weeks ago,  I got to read  Scott Rychnovsky's 
refutation of the Hexacyclinol original structure, using  geometries optimised 
at  HF/3-21G
and GIAO done at mpw1pw91/6-31G(d,p)  (the Bifulco protocol!).
He obtained a mean absolute deviation of  1.8 ppm for the  23  13C
shifts, and a  maxi absolute deviation of  5.4.   This was generally
accepted by the community as a convincing proof of the new
structure, aided by biosynthetic evidence.  It was subsequently confirmed
by  X-Ray.

Scott did three things, two brave, and one unnecessary

1. He picked a  "high energy conformation" for a side chain
as giving the better fit.  The X-ray vindicated this
2. He transposed two assignments
3. He "corrected" the predicted shifts by LS calibration against the
obs shifts, and then obtained the  1.8 ppm MAD from the  "corrected"
predictions.  The article makes for an interesting read in this regard;
we can perhaps forgive the liberties he took with statistics because he
is a  "synthetic organic chemist".

A quick read of this paper immediately suggested improvements, which
I tried out

1. To use  6-31G(d,p) geometries.
2. To apply a solvation correction for chloroform.  This has the greatest
impact upon carbonyls, often improving them by   3-5 ppm.
3. To dispense with all "correction factors".

This yield a  MAD for hexacyclinol of  0.9 ppm, with a max deviation of
2.8 ppm.

I wrote to  Scott with these results, and he agreed to all the points.  We
are planning a number of projects from this.

It has transpired that hexacyclinol was a "lucky" choice.  Systematic
errors started emerging from the above protocol

1. The method is sensitive to conformation.  Positively, it can be used
as a real conformational analysis tool, but negatively, it can mean a
LOT of work. This is of course generally recognised.
2.  The 6-31G(d,p) basis is also a lucky one; a great deal of cancelation
of errors occurs.  Thus ramping up to  aug-cc-pVTZ is a disaster
(because some errors are removed, leaving no cancellation!)
3. We find the aug-cc-pVDZ is better, especially for esters, amides etc.
But it can be a pathologically bad SCF converger! 

I could go on and on,  but the above should suffice, if only to set out
how "science really works".  The above was achieved by active
collaboration between only two people, and it has to be said
an imperfect searching of the literature by one of them!  The result is a 
practical
(rather than theoretically sound) protocol.  I agree totally that if
we open this up, then the improvements could both come
more quickly, and hopefully also be more soundly based
theoretically.
-- 

Henry Rzepa.
+44 (020) 7594 5774 (Voice); +44 (0870) 132 3747 (eFax); [EMAIL PROTECTED] 
(iChat)
 http://www.ch.ic.ac.uk/rzepa/ Dept. Chemistry, Imperial College London, SW7  
2AZ, UK.

(Voracious anti-spam filter in operation for received email.
If expected reply not received, please phone/fax).


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