On Feb 16, 2010, at 1:43 PM, Andrew Dalke wrote:

> On Feb 16, 2010, at 5:21 PM, Andrew Dalke wrote:
>> I thought the first version was published in a journal article, and
>> for the last 10 years I've not had problems getting the spec. There
>> was a period where I had to give them my contact details, but that
>> changed years ago.
>
> In addition, John Barnard in
>
> Structure Representation and Search, In Encyclopedia of  
> Computational Chemistry, Schleyer, P. von R.; Allinger, N. L.;  
> Clark, T.; Gasteiger, J.; Kollman, P. A.; Schaefer, H. F.; Shreiner,  
> P. R. (Eds.). Wiley, Chichester, 4, 2818-2826
>
> wrote:
>
> Among the formats which, at the time of writing (April 1997), appear
> to have some degree of general use, are:
>
> *   The Molfile and associated formats, developed by MDL Information
>   Systems, Inc., and maintained and supported by them as proprietary
>   commercial products, but whose description is made freely available
>   to other developers.
>
>
> then goes on to list PDB, CIF/mmCIF, MIF, CXF, CML, and CEX as other  
> connection table formats.
>
> So while Peter Murray Rust wrote:
>> MDL were incredibly secretive and possessive about the MOL-file  
>> format.
>
>
> I just don't see that in the historical record either.



I remember Bill Milne telling me a long time ago that there was some  
arm twisting done to get the original JCICS paper done, but it  
whatever the specifics of history (and that was probably 4 ownership  
changes ago), we have had 15+ years of actual experience with this  
format and I certainly have had no problems in either getting the  
specification or freely implementing the specification. It may be  
different for commercial operations and as I mentioned in the other  
note, I have never had any desire to modify it. I also have not had  
any complaints from anyone trying to use the DTP data that they  
couldn't use their software of choice to read the data.

DanZ


/********************************************
  *  Daniel Zaharevitz
  * Chief, Information Technology Branch
  * Developmental Therapeutics Program
  * National Cancer Institute
  * [email protected]
  *
  ********************************************/




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