I think this would be possible.
Each instance would need to run in its own data directory,
and you'd need to use <allow_multiple_clients> in the cc_config.xml.
You could use the <ignore_cuda_dev> config option to select a particular GPU.

-- David

> ... Could I run two instances of Boinc on that host and restrict one
> instance to one GPU and the second instance to the other GPU?
>
> :-)
>
>
> Happy crunchin',
> Martin
>
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