The Multi-Tasker 
  
Health Sciences Institute e-Alert 

September 22, 2004

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Dear Reader,

Even if you're never ordered Exercise-in-a-Bottle from an 
infomercial at 3 a.m. or stopped by the Metabolife kiosk at your 
local mall, you may already be taking a supplement that can help 
you lose weight. 

Earlier this month, researchers for the Fred Hutchinson Cancer 
Research Center in Seattle announced the results of study, 
involving nearly 15,000 subjects with an average age of 55. After 
following the subjects' medical histories, diets and supplement 
intakes for about ten years, the Hutchinson team found four 
supplements that were associated with weight reduction among 
subjects who were overweight or obese at the outset of the study. 

The diet-friendly supplements: multivitamins, chromium, and 
vitamins B-6 and B-12. 

When I read this list, I couldn't help but notice that the latter three 
items are often found in high quality multivitamins. So, many 
people who already take a good multivitamin may be getting an 
unexpected assist in their efforts to lose weight. 

But that's certainly not all they're getting. In recent months, 
research has produced evidence that multivitamins enhance general 
good health while providing protection from a common type of 
cancer. 

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Going long 
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Multivitamin use over long periods has been associated with 
decreased risk of colorectal cancer in previous research. So 
researchers at the American Cancer Society (ACS) designed a 
study to further investigate this relationship. 
 
In 1992, ACS researchers enrolled more than 145,000 men and 
women to participate in a five-year multivitamin study. All of 
these subjects had also participated in the Cancer Prevention Study 
II Nutrition Cohort (begun a decade earlier) in which their 
multivitamin usage was recorded.  
 
As reported in the American Journal of Epidemiology, 797 cases 
of colorectal cancer were reported among the study group between 
1992 and 1997. After adjusting for risk factors, researchers found 
that multivitamin use that began just prior to the 1992 enrollment 
was not associated with a reduced risk of colorectal cancer. But the 
participants who had reported regular multivitamin use (4 or more 
times per week) in the early 80s, fared much better: their group had 
a 30 percent reduced risk of the cancer.  
 
The researchers say that further studies are necessary to establish 
clear evidence that long-term multivitamin use is associated with a 
reduced risk of colorectal cancer. Also unknown is just how the 
nutrients in multivitamins combine to offer protection. I'm sure 
we'll see more research in this area in the future, so I'll be keeping 
an eye out for those results. 

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Multiplying the savings  
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Meanwhile, another 2003 study found a strong association 
between general good health and multivitamin use.  
 
The study was conducted by the Lewin Group (a healthcare 
consulting firm), and funded by a subsidiary of the Wyeth 
pharmaceutical company; Wyeth Consumer Healthcare, which 
manufactures about 10 percent of the vitamin supplements made in 
the U.S. Researchers analyzed more than 125 clinical studies and 
additional scientific literature to determine the health benefits of 
multivitamins, and the subsequent savings in healthcare bills for 
people 65 and older.  
 
The Lewin report was presented at a Washington, D.C. meeting 
titled "Multivitamins and Public Health: Exploring the Evidence." 
Researchers said that based on demonstrated multivitamin 
protection from the risk of coronary artery disease, as well as 
benefits to the immune system, they projected a five-year Medicare 
savings of more than $1.6 billion if all U.S. citizens over the age of 
65 took a daily multi.  
 
But the actual savings could be much higher. In their calculations, 
researchers didn't include expenditures associated with diabetes, 
osteoporosis, prostate cancer, and colorectal cancer, because, based 
on the sources they used, they couldn't conclude that multivitamins 
have a direct preventive effect on those health problems. (The 
Lewin team didn't have access to the ACS colorectal cancer study, 
which was released the same week.)  
 
These results were put into perspective by the director of 
Healthcare Finance for the Lewin Group, Allen Dobson, Ph.D., 
who told meeting attendees that in his experience, "finding any 
cost savings for preventive measures is unusual and finding cost 
savings of this magnitude is very rare."  

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Supplement checklist 
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Clearly, it makes sense to take a good multivitamin every day. It's 
inexpensive, it can't do any harm, and as we've seen above, the 
evidence is mounting that long-term multivitamin use may provide 
a host of positive health benefits.  
 
This isn't news to HSI members, of course. But for those of you 
who may have missed some of the many vitamin tips from HSI 
Panelist Allan Spreen, M.D., I've collected a few of the most 
important ones to help you choose the most effective multi.  
 
* Avoid a multivitamin that's a hard pill. Dr. Spreen says, "There 
are a few (read that a FEW) pill forms that break down quickly, but 
they are rare. I always use capsule, powder or liquid forms 
whenever possible, as they at least guarantee that the individual 
gets what he swallows."  
 
* Avoid time-release vitamins. Dr. Spreen: "I don't use time- 
release forms, as you're then using a preparation deliberately 
designed not to give its contents to you. I prefer to have the 
individual be his own 'time-releaser' by multiple dosing throughout 
the day."  
 
* Vitamins are absorbed more efficiently when taken with meals. 
Dr. Spreen: "They are better digested that way (they're food 
supplements)."  
 
* Avoid getting too much iron. Dr. Spreen: "Concerning multi- 
vitamin/mineral preparations there can be one problem, and that's 
iron. It's too high, in my opinion, for most everyone as it is a 
known generator of free radicals in biological systems (if it's 
inorganic iron as most are in supplements)." 

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...and another thing
 
With autumn just around the corner, this is a perfect time to find 
ways to relax and take it easy. 

In the journal Psychotherapy and Psychosomatics, I came across a 
study that demonstrates the positive effects that stress management 
can have on levels of antibodies; the proteins produced by the 
immune system to fight disease.  
 
UK researchers recruited 43 subjects over the age of 65, who also 
cared for spouses with dementia (a high-stress duty that's 
associated with a vulnerability to colds and flu). Half the subjects 
attended a stress management course for two months. At the 
conclusion of the course, all 43 subjects were given flu shots. An 
additional control group of 43 subjects was also given shots. The 
subjects in this group were of the same age and relative health, but 
didn't provide special care for family members.  
 
50 percent of the stress-management group produced antibody 
counts believed to be high enough to effectively protect against the 
flu virus. Only 7 percent of the group that didn't take the course 
produced the same high levels of antibodies. Most interesting was 
the response from the control group. Less than 30 percent of that 
group matched the best antibody levels of the stress-management 
group.  
 
In short: Learning how to smooth out those stressful kinks could 
make for a flu-free flu season.  
 
As the days grow shorter and we advance further into the "bug" 
season, I'll keep a lookout for other research and commentary on 
ways to help make your immune system a strong first line of 
defense.  

To Your Good Health,

Jenny Thompson
Health Sciences Institute 

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To start receiving your own copy of the HSI e-Alert, visit:
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Or forward this e-mail to a friend so they can sign-up to
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Sources:  
"Chromium, B Vitamins Could Reduce Middle-Aged Spread" 
NutraIngredients.com, 9/14/04, nutraingredients.com 
"Multivitamin Use and Colorectal Cancer Incidence in a US 
Cohort: Does Timing Matter?" American Journal of Epidemiology 
2003; 158:621-628, aje.oupjournals.org  
"Timing Key to Multivitamin Benefits" NutraIngredients.com, 
10/8/03, nutraingredients.com  
"A Study of the Cost Effects of Daily Multivitamins for Older 
Adults" The Lewin Group, 10/2/03, lewin.com  
"Analysis: Multivitamins Good but Who Pays?" Ellen Beck, 
United Press International, 10/2/03, washingtontimes.com  
"New Study Finds Increased Multivitamin Use by the Elderly 
Could Save Medicare $1.6 Billion" PR Newswire, 10/2/03, 
prnewswire.com
"Aging: A Lesson for the Immune System" John O'Neil, The New 
York Times, 9/23/03, nytimes.com

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AOL HTML links
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<a href="http://www.youreletters.com/t/60579/3786805/648581/0/";>Banned! Why the FDA 
slammed the door on nature�s best cholesterol buster�</a>
<a href="http://www.youreletters.com/t/60579/3786805/648582/0/";>DRIVE OUT TOXINS AND 
FEEL BRAND NEW</a>

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