Hi Donald, & Dav,

As far as I know, neither Fischl et. al. nor VE et. al. has taken this
task on seriously.  I vaguely recall someone from MGH registering for
Caret a while back with the research goal of comparing registration
methods. I haven't heard anything since then, and I didn't recognize the
name.

My instincts for approaching the problem are to get source, Caret
deformed, and FS deformed coords all on the same mesh, and then compute
distance from deformed to the source.  (DVE probably would use distortion
between deformed and source.)  The method that minimizes distance to the
source (or distortion) wins.  But of course getting all on the same mesh
requires registration, and you could easily introduce more error than you
are measuring.

I have read Arno's paper, which is interesting, but it covers volumetric
algorithms (using Freesurfer in the process, though).  I've shared some
ideas with Arno for additional analyses he could do with this data, but he
has plenty on his plate already.  I believe Arno is planning to evaluate
surface-based methods, but only fully automated ones.  He regularly
hassles me about whether our auto-landmark algorithm is ready for him to
try (not yet, but maybe by August?).

One can hypothesize about which method might do better for given
applications.  But evidence to support those hypotheses is lacking so far.

It's a very important, but tough problem.

Donna

> Arno Klein is engaged in a fairly ambitious project of comparing
> various registration algorithms.  So, while it's not exactly what
> you're asking about, I figure it's worth mentioning:
>
> http://www.mindboggle.info/
>
> Check out the papers link.  He uses hand-labelled data, though, so
> there may be some differences with your particular needs.
>
> Cheers,
> Dav
>
> On Jun 5, 2009, at 11:27 AM, MCLAREN, Donald wrote:
>
>> David/Donna/John:
>>
>> Have any of you or perhaps Bruce compared the registration
>> algorithms of CARET and Freesurfer using their segments? If not, is
>> there a good metric to decide what registration might be better?
>>
>> --
>> Best Regards, Donald McLaren
>> =====================
>> D.G. McLaren
>> University of Wisconsin - Madison
>> Neuroscience Training Program
>> Office: (608) 265-9672
>> Lab: (608) 256-1901 ext 12914
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