Hi Matt,

Using the linear transformation I noticed some severe misplacements of structures, so that I do not trust the results. With a nonlinear transformation, all structures seem to match far better. Here again, I think with primate fMRI different standards might apply compared to human MRI. Since the brain morphology of primates is very similiar, I do expect that sulci match exactly. This was not the case with Flirt, but did work with Fnirt. However, it was necessary to play around with the fnirt parameter a bit to achieve good results.

Hope this helps,
wolf



On 05/13/2010 01:52 AM, R. Matthew Hutchison wrote:
Thanks for the help everyone.

Wolf: I was wondering why you chose to do a nonlinear transform (FNIRT) as opposed to the linear (FLIRT) transform.
Is non linear better when registering to an atlas?

Thank you all again,

Matt Hutchison

On Wed, May 12, 2010 at 1:01 PM, wolf zinke <[email protected] <mailto:[email protected]>> wrote:

    Hi Matthew,


    On 05/12/2010 09:51 AM, R. Matthew Hutchison wrote:
    Hi group,

    I am starting with Caret and have gone through most of the
    tutorials using the data sets provided. The images are fantastic.
    The part I seem to be missing is actually getting *my* activation
    maps so that I can view them on the inflated surfaces.
    If you use the menu 'Attributes', you'll find at the bottom 'Map
    Volumes(s) to Surface'. I guess that is what you want. Took me a
    while to find it as well ;-) .

    I was wondering if anyone has a guide, steps, or hints in
    converting the output files from FSL FEAT (registered to a
    standard atlas using FSL FLIRT) to files viewable with Caret.
    It seems this is not included in the tutorials.
    T map macaque data of my individual monkeys to the caret F99
    atlas, I used FSL's FNIRT for a nonlinear transformation. Doing
    this once in a way, that I was somehow satisfied with the result
    allows me to apply the transformation on the statistical maps, if
    they are in the individual monkey space. However, You might want
    to use the F99 atlas already as standard template in the Feat
    analysis (if it yields convincing results).

    I attached a small script that transforms a set of nii.gz-Nifti
    files found within a directory into a new space according to a
    Flirt transformation matrix file (linear) or a 3D volume with
    warp-coefficients (Fnirt, nonlinear). Maybe this gives you an
    idea. I cannot guarantee that it is bugfree, but at least It did
    work for me.


    A search of the archive does not turn up any recent information
    on the issue that I could find.

    I am actually using macaque data but I figure the steps should be
    the same as with the human but using the F99 atlas.
    Perhaps I am just missing something obvious?

    I understand that my data must be registered to the atlas space
    that I wish to use in Caret.
    But which FSL file should be used and what is the next step so
    that I can view them?
    If it is registered to the atlas then there should be no need to
    segment the volumes again right?
    You can use the zstat* images in the stats subdirecory of your
    copes as statistical map that you transform to the standars F99
    space. In this case you can utilize the F99 segmentation, without
    segmenting the individual brains. However, in my opinion you are
    loosing the specificity of the localization, which in my view is
    one of the huge advantages of primate fMRI. So I do both, mapping
    data on individual brains, but also map all individuals on the
    standard atlas for comparision.


    Thank you for any help (and patience for a novice),
    I hope this gives you some pointers. Good luck anyway,
    wolf


    R.Matt Hutchison


-- R. Matthew Hutchison, PhD. Candidate
    Centre for Functional and Metabolic Mapping
    Robarts Research Institute
    Cuddy Wing - 9.4T Suite
    P.O. Box 5015, 100 Perth Drive
    London, Ontario, Canada  N6A 5K8


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--
R. Matthew Hutchison, PhD. Candidate
Centre for Functional and Metabolic Mapping
Robarts Research Institute
Cuddy Wing - 9.4T Suite
P.O. Box 5015, 100 Perth Drive
London, Ontario, Canada  N6A 5K8


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