Joost,

In addition to Donna's pointers, check out:
Van Essen, D.C., Dierker, D., Snyder, A., Raichle, M.E., Reiss, A., and 
Korenberg, J. (2006) Symmetry of cortical folding abnormalities in Williams 
syndrome revealed by surface-based analyses. J. Neuroscience 26:5470-5483
It shows how significant group differences in sulcal depth can be ascertained 
despite large regional variability.

DVE

On Jul 5, 2010, at 12:46 PM, Donna Dierker wrote:

> Hi Joost,
> 
> Define "considerable amount."  Does 92 count?  If so, then yes, but this 
> hasn't been published.  (It's part of an ADHD vs control manuscript that 
> hasn't yet been submitted.)  And we hadn't really planned to cover 
> normal variability as a part of that paper.
> 
> David did publish some figures on this in his PALS paper:
> 
> Van Essen, D.C. (2005) A population-average, landmark- and surface-based 
> (PALS) atlas of human cerebral cortex. Neuroimage 28: 635-662.
> http://brainvis.wustl.edu/resources/-Pals.wcover.pdf
> see figure 6
> 
> But the number of subjects was either 12 or 24.  Qualitatively, the 
> variability maps look similar once n>=12.  They just get smoother the 
> larger n gets.
> 
> Donna
> PS Nice talk at OHBM
> 
> On 07/05/2010 06:53 AM, j janssen wrote:
>> Hi,
>> 
>> i searched publications measuring sulcal depth but could not find a
>> good answer: has sulcal depth been mapped (vertex-wise) in a
>> considerable amount of healthy subjects to see how it variates over
>> the cortex (akin to e.g. cortical thickness which varies over the
>> cortex in healthy subjects, i.e. thicker inferior temporal and thinner
>> post central)? maybe you guys at wustl mapped and normalized a bunch
>> of healthy subjects to see how it varies over the cortex?
>> 
>> thanks!
>> -joost
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>> 
> 
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