Northern Ireland scientists find a new weapon in MRSA war

<http://www.belfasttelegraph.co.uk/news/health/northern-ireland-scientists-find-a-new-weapon-in-mrsa-war-14241114.html>http://www.belfasttelegraph.co.uk/news/health/northern-ireland-scientists-find-a-new-weapon-in-mrsa-war-14241114.html
 


By Lesley-Anne Henry
Wednesday, 25 March 2009

A new weapon that could help wipe out the deadly 
MRSA virus has been developed by researchers from Northern Ireland.

Experts from Queen’s University have discovered 
new agents that can kill colonies of MRSA and 
other antiboitic resistant hospital-acquired |infections.

The antimicrobial agents also prevent any growth 
of the potentially lethal bacteria.

The breakthrough was made by a team of eight 
researchers from the Queen's University Ionic 
Liquid Laboratories (QUILL) Research Centre led 
by Brendan Gilmore, a lecturer in Pharmaceutics, 
and assistant director of QUILL Dr Martyn Earle. 
The discovery has been published in the |scientific journal, Green Chemistry.

Dr Earle said: “We have shown that, when pitted 
against the ionic liquids we developed and 
tested, biofilms offer little or no protection to 
MRSA, or to seven other infectious microorganisms.

“Our goal is to design ionic liquids with the 
lowest possible toxicity to humans while wiping 
out colonies of bacteria that cause hospital acquired infections.”

Many types of bacteria, such as MRSA, exist in 
colonies that stick to the surfaces of materials. 
The colonies often form coatings, known as 
biofilms, which protect them from antiseptics, disinfectant, and |antibiotics.

Ionic liquids, just like the table salt sprinkled 
on food are salts. They consist entirely of ions 
­ electrically-charged atoms or groups of atoms. 
Unlike table salt, however, which has to be 
heated to over 800 degrees celsius to become a 
liquid, the ionic |liquid antibiofilm agents 
remain |liquid at the ambient temperatures found in hospitals.

One of the attractions of ionic liquids is the 
opportunity to tailor their physical, chemical, 
and biological properties by building specific 
features into the chemical structures of the 
positively-charged ions (the cations), and/or the 
negatively-charged ions (the anions).

Microbial biofilms are not only problematic in 
hospitals, but can also grow inside water pipes 
and cause pipe blockages in industrial processes.

Mr Gilmore added: “Ionic liquid based antibiofilm 
agents could potentially be used for a multitude 
of medical and industrial applications. For 
example, they could be used to improve infection 
control and reduce patient morbidity in hospitals 
and therefore lighten the financial burden to 
healthcare providers. They could also be 
harnessed to improve industrial productivity by 
reducing biofouling and microbial-induced corrosion of processing systems.”

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