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Here's a silly question, can the max likelyhood target for some reason perform poorly if the intensity distribution is skewed (not twinned but e.g. if there is NCS parallel to crystal axis or translational NCS/speudo-centering) and might any other "old-fashioned" method work better or no? I didnt do the empiric test yet but i am curious. at 2.0 A (1.85 A actually) with 2-fold NCS close to one crystal axis looks like our Rfree is stuck at 30% (and ARP explodes to Rfree 40-45 at 1.85). space group is C2, ideas are welcome, beta=107, cell approx. a=71 b=70 c=68 so probably not twinned. not severely anisotropic either. Unless it woudl be P1, which with current stats seems unlikely (considering also the I-distribution and 2nd moment of E 2.5. (although the value goes up with resolution which i dont quite understand either..) Data looks fine otherwise to 1.85 (Rsym etc). ..but maybe it is P1. thanks for comments, tommi
