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Scientist Structural Biochemistry (PhD) We seek a scientist to work in a Structural Biochemistry team to perform research on RNA binding DExD/H-box helicases, AAA-ATPases, PARPs and amino acid metabolic enzymes. Tasks will include bioinformatic analyses of target proteins, construct design, bacterial expression, purification, characterisation, crystallisation and structure determination as well as functional analysis. Candidates should have a PhD and preferably some post doctoral experience and an excellent publication record. •Solid track record within structural biology (protein crystallisation and structure determination) •Proven laboratory skills in protein biochemistry and molecular biology •Excellent communication skills •Innovative, analytical and goal oriented Starting date: July/August 2006 The position is temporary (parental leave replacement) and limited to 8 months. For further information contact Dr. Lovisa Holmberg Schiavone, Team Leader (+46 8 524 86867, [EMAIL PROTECTED]) or Dr. Johan Weigelt, Chief Scientist (+46 8 524 86840, [EMAIL PROTECTED]). Union representative for SACO is prof. Tomas Cronholm, (+46 8 524 877 33, [EMAIL PROTECTED]). Please send your application to Karolinska Institutet MBB/Structural Genomics Consortium 171 77 Stockholm Mark the application with reference No: Dnr 02077/2006 Application deadline: Thursday April 13th 2006 A list of at least two reference persons should be included. The Structural Genomics Consortium (SGC) is a not-for-profit organization that aims to determine the three dimensional structures of proteins of medical relevance, and place them in the public domain without restriction. The initiative was launched in Oxford and Toronto in April 2003 with funding from Canadian and British sponsors from both the public and private sectors (The Wellcome Trust, GlaxoSmithKline, Genome Canada, the Ontario Research and Development Challenge Fund, the Ontario Innovation Trust and the Canadian Institutes of Health Research). In 2005, a consortium of Swedish sponsors (VINNOVA, SSF, KAW and KI) provided funds to the SGC and a Swedish node was launched at Karolinska Institutet. The goal of the SGC is to develop the infrastructure and technologies necessary for rapid, parallel structure determination, with the aim of having the capability to determine more than 200 protein structures per year. Over the first three years, the SGC is targeting 400 proteins that have relevance to human health and disease, such as proteins associated with diabetes, cancer, and infectious diseases such as malaria. Targets are also chosen based on interest from the academic and pharmaceutical communities, expertise within the Consortium and scientific impact.
