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Three comments about "observations" (just to point out a few other aspects of "observations", etc): 1. Reflections with zero intensities are useful in refinement, even if they don't contribute much to Fo maps. They provide important restraints on the electron density. 2. I've slowly discovered that some data reduction programs count partials as "measurements". I understand why you'd do that, but it's a tad confusing when the number of measured reflections gets so large. 3. And another slow realization on my part is that our cryo-EM colleagues have a wonderful way to increase their number of observations. They pick an arbitrary (or at least it looks that way to my un-trained eyes) grid in reciprocal space to sample their diffraction pattern perpendicular to the 2-d crystals. There must be some guidelines for acceptable choices for that sampling interval, but if they change it a little, they can change their number of observations by large numbers. Ron
