Postdoctoral Position: Structural basis of protein-protein interactions in the Z-disk of a striated muscle

Starting date: As soon as possible after the 1st September 2006

We are seeking a highly motivated post-doctoral fellow to structurally characterize several important protein complexes centered on major players of the Z-disk of striated muscle: alpha-actinin, titin and telethonin. This is a collaborative effort with M. Wilmanns’ group at EMBL-Hamburg and close interactions with the EMBL-Hamburg group will be ensured at all stages of the project.  Binary and higher complexes with interacting partners or domains of interacting partners will be produced for structural analysis. The individual proteins or their domains planned for this study are already available in a form of clone or expressed protein in the two laboratories. An integrated approach will be adopted to gain structural information on target complexes, by using all structural biology techniques available at both laboratories.

The successful applicant will work in a stimulating scientific environment at the Macromolecular crystallography Group at the Department of Biomolecular Structural Chemistry, a member of Faculty of Chemistry and of Max F. Perutz Laboratories - University Departments at the Vienna Biocenter, University of Vienna. The Department is equipped to carry out all steps from gene cloning, to structural analysis including X-ray diffraction facility, biomolecular NMR facility, and a series of biophysical and optical spectroscopy techniques.  The Group has additionally access to the high throughput nano-drop crystallisation robotics operational at Institute of Molecular Pathology (IMP), based at Campus Vienna Biocenter as well as to major European synchrotron high brilliance X-ray sources.

Qualifications and experience: a Ph.D. in biochemistry, molecular biology, or a related field, with a strong background in molecular biology, protein _expression_/purification and biophysical/biochemical characterization are required. Experience in eukaryotic cell culture and macromolecular crystallography techniques are a plus.

Contract: A 2.5 year contract will be offered to the successful candidate.

Closing date: Review of applications begins June 30th, 2006 and will continue until the position is filled.

Web pages:

http://www.mfpl.ac.at/index.php?cid=58

http://www.univie.ac.at/biolchem

University of Vienna is an equal opportunity employer.

To apply for this position, please email a detailed CV with concise description of research experience and interests; arrange for two letters of recommendation to be sent to Kristina Djinovic Carugo via email < [EMAIL PROTECTED]>,  ****AND**** register at the University of Vienna: http://gerda.univie.ac.at/personal/artikel.php?Sprach_ID=1&Art_ID=668

Further information can be obtained from Kristina Djinovic Carugo  [EMAIL PROTECTED].

-- 

**********************************************
Max F. Perutz Laboratories
University Departments at the Vienna Biocenter
Department for Biomolecular Structural Chemistry
Faculty of Chemistry, University of Vienna
Campus Vienna Biocenter 5
A-1030 Vienna
Austria

e-mail: [EMAIL PROTECTED]
Phone: +43-1-4277-52203 
Mobile A: +43 699 10 66 38 56
Fax: +43-1-4277-9522
Home home: + 43 1 208 71 77

Reply via email to