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Hi, could I please draw your attention to these two post doc research
associate posts at the University of Manchester.
The Faculty of Life Sciences has excellent core research facilities
including state of the art mass spectometry and x-ray diffraction equipment.
Quote ref: LS/090/06
THE UNIVERSITY OF MANCHESTER
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*PARTICULARS OF APPOINTMENT*
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*Faculty of Life Sciences *
*Wellcome Trust Centre for Cell Matrix Research*
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_Research Associate (Two Posts)_
_Ref: LS/090/06 _
The University invites applications for the above post which is tenable
for up to three years
Salary will be within the range £20,235 – £28,009 per annum according to
experience.
3 Informal enquiries can be made to Professor Tony Day
[EMAIL PROTECTED] <mailto:[EMAIL PROTECTED]>
Tel +44 (0) 1865 275 349
Applications should be returned by 30^th June 2006 to:
Miss Carol Bennett
Faculty of Life Sciences
University of Manchester
Michael Smith Building
Oxford Road
Manchester M13 9PT
UK
[EMAIL PROTECTED]
<mailto:[EMAIL PROTECTED]>
Tel: +44 (0) 161 275 7513.
Unfortunately, it is not possible for the University to contact all
unsuccessful applicants. If you have not been contacted within 6 weeks
of the closing date you should assume that, on this occasion, your
application has not been successful. We would, however, like to take
this opportunity to thank you for your interest in The University of
Manchester.
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*POSTDOCTORAL RESEARCH ASSOCIATE – Further Particulars*
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*1. The Environment*
The Faculty of Life Sciences is one of the largest and most successful
unified research and teaching organisations of its kind in Europe.
Research spans all fields of biology, with a strong emphasis on a
collaborative integrative approach. Our unified structure and single
site location promote collaboration and facilitates centralised
provision of state of the art equipment.
The Faculty of Life Sciences places considerable emphasis on the
provision of personal and transferable skills at all levels thereby
providing an important interface between research and education. The
postdoctoral training programme includes a series of workshops
encompassing interview/interviewing skills, appraisal skills,
presentation and writing skills.
The Wellcome Trust Centre for Cell-Matrix Research
http://www.manchester.ac.uk/wtccmr is an interdisciplinary research
centre embedded within the Faculty of Life Sciences at the University of
Manchester. The Centre was established in 1995 with the long-term aims
of elucidating the structure and function of extracellular matrices and
cell-matrix adhesions, defining the contribution of cell-matrix
interactions to human diseases, and developing approaches for preventing
and treating these diseases.
*2. The Project*
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*/Hyaluronan-binding proteins in cartilage matrix organisation and
leukocyte migration–/*The aim of this 3-year project, which forms part
of an on-going Programme Grant from the Arthritis Research Campaign, is
to investigate the structures and functions of hyaluronan-binding
proteins involved in leukocyte migration and the assembly/stability of
cartilage matrix. A major focus will be the inflammation-associated
protein TSG-6, which has potent anti-inflammatory and chondroprotective
functions in models of arthritis, arising through its control of the
protease network, regulation of leukocyte migration and extracellular
matrix remodelling. Here the molecular/structural basis of TSG-6’s
diverse functional properties will be investigated, in particular with
regard to its ligand-binding activities and the formation of
multi-molecular complexes. These studies should aid in the development
of novel therapeutic strategies for arthritic disease.
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*3. Job Content*
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Analysis of protein-protein and protein-glycosaminoglycan interactions
by techniques including surface plasmon resonance, isothermal titration
calorimetry, multi-angle laser light scattering, analytical
ultracentrifugation, mass spectrometry and nuclear magnetic resonance
spectroscopy. The structural determination of protein-ligand complexes
by X-ray crystallography.
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*4. Person Specification*
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* Education*
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PhD in Structural Biochemistry or Biophysics
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* Experience*
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2-3* *years post-doctoral experience in molecular biochemistry.
Expertise in X-ray crystallography and/or NMR spectroscopy would be a
particular advantage.
* *
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*Personal Qualities*
* *
You will be an enthusiastic and hard-working individual with broad
interests in structural and matrix biology. Good verbal and written
communication skills are essential; you will be expected to present your
results at lab meetings, seminar series within the Centre/Faculty and at
National/International meetings, as well as in the form of research
publications. You should be able to interact in a positive way with
other lab members and be willing to provide some supervision of project
students as appropriate.**
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--
Dr Patrick Buckley
Faculty of Life Sciences
University of Manchester
Michael Smith Building
Oxford Road
Manchester, M13 9PT
