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Taiana Oliveira wrote:
Hi everybody,
I would like for you to clarify me abou the I/sigma value. I found
articles saying that resolutions with value below 2.0 must be discarded
but that for maxium likelihood methods this rule may be ignored. How to
proceed? What values may be considered as limits in this case?
In my experience a value of 2.0 is conservative and seems to be used
mostly to avoid arguments with reviewers. There is not a hard cutoff
value but I think you're likely ok to 1.5. As the I/SigI goes down the
information content gets lower but maximum likelihood shoult account for
that. Check Rfree in the highest resolution shell to make sure there is
at least some correlation between model and observations.
Bart
==============================================================================
Bart Hazes (Assistant Professor)
Dept. of Medical Microbiology & Immunology
University of Alberta
1-15 Medical Sciences Building
Edmonton, Alberta
Canada, T6G 2H7
phone: 1-780-492-0042
fax: 1-780-492-7521
==============================================================================
