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Hi -
here is my summary of responses, after reading the suggested works -
could be useful for others:
I really liked "An Introduction to Medicinal Chemistry", by Graham L.
Patrick,
although I had procured the second edition which was a bit outdated as
far as the examples go. I really liked the simple but very thoughtful
diagrams
of receptor/enzyme/ligand interactions etc, and the book has an implicit
bias
towards the importance of structure. Would be my first choice for
a introductory course.
More advanced, Silverman's 2nd ed "The organic chemistry of drug design and
drug action"
is a pleasure to read. I also treats the basics well, and then continues to
more advanced subjects like drug interaction, delivery, and general ADME/T.
The examples were up to date. However, to really appreciate this text,
you need a solid knowledge of organic chemistry. I personally don't, and
I have a hard time following this electron shifting business. It blows
my mind how some dudes can figure out what might happen if you put some
decidedly weird molecules together.....
Definitely upper level.
I also read the Nogrady "Medicinal Chemistry" but did not like it very much
compared to the others. I had the 1988 edition, and that may explain it.
Interestingly, all the books I bought we used and 'annotated'. The
annotations
largely were in the introductory chapters and included anything with
"drugs".
Morphine, THC, XTC, you name it. Then the annotations stopped in the hard
core
sections....
Thx, br
-----Original Message-----
From: Bret Church [mailto:[EMAIL PROTECTED]
Sent: Wednesday, October 04, 2006 6:14 PM
To: [EMAIL PROTECTED]; 'Bulletin Board CCP4'
Subject: Re: [ccp4bb]: PharmChem text
