Hi,all:
During water-tidy, I found a big bulb of density in my active site(only a
bit in 2Fo-Fc map but quite big in Fo-Fc above 3.5sigma level).This looks
pretty much like my ligand. Then I put it in and start refinement, but the
program always give a high B-factor for this ligand(above 100).From the
difference map, I'm convinced I have the ligand there but how to get it refined
with a reasonable B-factor?Please advise.
Mike
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