Hi Lionel Definitely an engineered example for you: This is a paper describing (among other things) the 3D structure of a ligand-induced homodimer of E. coli DHFR (a functional monomer), via covalent linkage of the ligands themselves.
Designing Protein Dimerizers: The Importance of Ligand Conformational Equilibria Jonathan C. T. Carlson, Aaron Kanter,Guruvasuthevan R. Thuduppathy,Vivian Cody, Pamela E. Pineda,R. Scott McIvor,and Carston R. Wagner J. Am. Chem. Soc., 125 (6), 1501 -1507, 2003 HTH, Brad -- Brad C Bennett Postdoctoral Research Assistant Department of Biochemistry, Cellular and Molecular Biology (BCMB) University of Tennessee-Knoxville 865-974-3045 [EMAIL PROTECTED] -------------- Original message from Lionel Mourey <[EMAIL PROTECTED]>: -------------- Dear all, I would be very interested and much grateful having references (bibliographic data, PDB entry code, web link...) on 3D structures of covalently linked (engineered or not) protein-protein complexes (e.g. heterodimers). Our own survey of the literature was not very "successful". Thanks for your help. Lionel Lionel Mourey e-mail: lionel dot mourey at ipbs dot fr Groupe de Biophysique Structurale Département "Mécanismes Moléculaires des Infections Mycobactériennes" IPBS-CNRS UMR 5089 / 205 route de Narbonne 31077 / TOULOUSE Cedex FRANCE Tel : +33 (0)561 175 436 Fax : +33 (0)561 175 994
