We are using a combination of X-ray crystallography and cryo-EM to determine the structures of eukaryotic ribosomes undergoing translation initiation and during elongation (refs 1,2). To help us further develop our programme, we are seeking to appoint a Post-Doctoral Research Assistant, initially funded for three years by the BBSRC. The project will build on recent work that has shown how eukaryotic translation initiation factors remodel the small subunit of the ribosome to give access to mRNA (ref. 2). The successful candidate will be expected to have experience in the structural analysis of macromolecular complexes, with a background in a major subdiscipline of structural biology.
(1) Namy et al. (2006) Nature 441, 244-247. (2) Gilbert et al. (2007) Proc. Nat’l Acad. Sci. USA 104, 5788-5793. For more information, see http://www.strubi.ox.ac.uk/people/gilbert. For informal inquiries email [EMAIL PROTECTED] A detailed job description quoting reference H5-07-018-RG is available from the Personnel Administrator (tel:01865 287508 email: [EMAIL PROTECTED], web http://www.well.ox.ac.uk/vacancies/index.shtml). Please send your letter of application with full curriculum vitae and the names and addresses of two referees quoting the above reference number to: The Personnel Administrator, The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN or by email to [EMAIL PROTECTED] or fax to 01865 287516. The closing date for applications is 11 May 2007.
