Hi, Please see the following reference. Does this answer your query?
http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/1999/121/i22/abs/ja990340o.html regards, gowri. -- V.S. Gowri, Ph.D Student, Prof. N. Srinivasan's Lab, Molecular Biophysics Unit, Indian Institute of Science, Bangalore - 560 012. Karnataka, India. Voice: 2293 2837 (Lab) Email: [EMAIL PROTECTED], [EMAIL PROTECTED] visit: www.sankalpindia.net ======================================================================================================================== > Dear All, > > We have solved a structure that has an intersubunit His-His H-bond > (ND1---NE2). The protein most likely undergoes conformational changes > that involve the making and breaking of H-bonds at this interface. In > all the protein structures I have previously studied I don't recall ever > seeing such a bond - His-His ring stacking yes, but never H-bonding. I > was wondering if anyone else had seen this type of interaction and > whether it had any functional significance. The crystals were grown at > pH 5.6. > > Many thanks > > Dave Lawson > > ------------------------------- > > Dr. David M. Lawson > Biological Chemistry Dept., > John Innes Centre, > Norwich, > NR4 7UH, UK. > Tel: +44-(0)1603-450725 > Fax: +44-(0)1603-450018 > Email: [EMAIL PROTECTED] > Web: http://www.jic.bbsrc.ac.uk/staff/david-lawson/index.htm > > > -- > This message has been scanned for viruses and > dangerous content by MailScanner, and is > believed to be clean. > >
