> If your Phaser results show a high Z-score (> 8) AND high LLG AND your > solution packs without clashes AND refines (even though starting R/Rfree > is high) AND reproduces density for the model portion AND produces some > Fo-Fc density for the missing portion, most probably your solution is > correct.
AND the z-score for your solution stands out from the z-scores for incorrect (/other) solutions. I've gotten z-scores > 8 for a known incorrect solution while testing (searching for a domain not present in the crystal, so this test was probably unrealisticly difficult). The highest/second highest z-scores for the incorrect domain were roughtly equal (~8.7/~8.2); for the correct domain they were ~ 35/7). So as long as you're checking phaser statistics, this is another one to check. Pete Pete Meyer Fu Lab BMCB grad student Cornell University
