Could such solvent ordering be a byproduct of unusually low solvent
content as both of the structures seem to have (1h6w & 1ocy)? Perhaps
cryoprotectant did not penetrate the solvent channels, but the
crystal maintained its integrity nevertheless?
On Aug 28, 2007, at 1:14 AM, Kevin Cowtan wrote:
Wow! Those are two pretty amazing structures.
For those of you who haven't had a look, the ordered molecules are
in layers with *huge* gaps in between, much greater than in 2hr0.
And yet both of these structures were solved with experimental
phasing (SIRAS) unlike 2hr0, and the data is to higher resolution.
Mark J. van Raaij wrote:
With regards to our structures 1H6W (1.9A) and 1OCY (1.5A), rather
than faith, I think the structure is held together by a real
mechanism, which however I can't explain. Like in the structure
Axel Brunger mentioned, there is appreciable diffuse scatter,
which imo deserves to be analysed by someone expert in the matter
(to whom, or anyone else, I would gladly supply the images which I
should still have on a tape or CD in the cupboard...). For low-res
version of one image see http://web.usc.es/~vanraaij/diff45kd.png
and http://web.usc.es/~vanraaij/diff45kdzoom.png
two possibilities I have been thinking about:
