Hi Miriam,
If you check PDB ID 1K50 you would see that the
asymmetric unit contains two monomers and a domain swapped dimmer. The
reference if you want to read the paper is:
O`Neill, J.W., Kim, D.E., Johnsen, K., Baker, D., Zhang,
K.Y. Single-site mutations induce 3D domain swapping in the B1 domain
of protein L from Peptostreptococcus magnus. Structure v9 pp.
1017-1027, 2001
Regards
Myron
-----Original Message-----
From: CCP4 bulletin board [mailto:[EMAIL PROTECTED] On Behalf Of
Miriam-Rose Ash
Sent: Friday, October 05, 2007 3:41 PM
To: [email protected]
Subject: [ccp4bb] Domain swapping..... and unswapping.
Hey all,
Sorry for the off-topic post, but I'm just wondering if anyone has heard
of any examples in which a single crystal contained both the
domain-swapped and unswapped forms of a protein?
Thanks!
Miriam
Disclaimer
This communication is confidential and may contain privileged information
intended solely for the named addressee(s). It may not be used or disclosed
except for the purpose for which it has been sent. If you are not the intended
recipient you must not review, use, disclose, copy, distribute or take any
action in reliance upon it. If you have received this communication in error,
please notify Astex Therapeutics Ltd by emailing [EMAIL PROTECTED] and destroy
all copies of the message and any attached documents.
Astex Therapeutics Ltd monitors, controls and protects all its messaging
traffic in compliance with its corporate email policy. The Company accepts no
liability or responsibility for any onward transmission or use of emails and
attachments having left the Astex Therapeutics domain. Unless expressly
stated, opinions in this message are those of the individual sender and not of
Astex Therapeutics Ltd. The recipient should check this email and any
attachments for the presence of computer viruses. Astex Therapeutics Ltd
accepts no liability for damage caused by any virus transmitted by this email.
E-mail is susceptible to data corruption, interception, unauthorized amendment,
and tampering, Astex Therapeutics Ltd only send and receive e-mails on the
basis that the Company is not liable for any such alteration or any
consequences thereof.
Astex Therapeutics Ltd., Registered in England at 436 Cambridge Science Park,
Cambridge CB4 0QA under number 3751674
